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Tag: S-adenosylmethionine

Toxic Metals and Antioxidants: Part II. The Role of Antioxidants in Arsenic and Cadmium Toxicity

This comprehensive review explores the mechanisms by which arsenic and cadmium exert toxic effects, primarily through oxidative stress and interference with essential metal ions. The article highlights the role of antioxidants and thiol-containing compounds in mitigating these toxicities. Key antioxidants discussed include S-adenosylmethionine, lipoic acid, glutathione, selenium, zinc, N-acetylcysteine (NAC),

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June 26, 2025 No Comments

Mechanisms of protection by the betaine-homocysteine methyltransferase/betaine system in HepG2 cells and primary mouse hepatocytes

This study examines the role of betaine-homocysteine methyltransferase (BHMT) and betaine in liver function, demonstrating that betaine supplementation enhances BHMT activity, reduces homocysteine levels, and increases S-adenosylmethionine (SAM) production. This metabolic shift protects liver cells from oxidative stress-induced apoptosis by reducing reactive oxygen species (ROS) and caspase activation. The findings

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June 26, 2025 No Comments

Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium

This symposium summary discusses the roles of S-adenosylmethionine (SAMe), folate, and betaine in treating alcoholic liver disease (ALD), focusing on their biochemical functions and therapeutic potential. These compounds act as methyl donors essential for hepatic transmethylation reactions, impacting homocysteine metabolism and influencing gene expression related to liver health. Deficiencies in

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June 26, 2025 No Comments