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Tag: rotenone

Intervention of mitochondrial dysfunction-oxidative stress-dependent apoptosis as a possible neuroprotective mechanism of α-lipoic acid against rotenone-induced parkinsonism and L-dopa toxicity

This 2011 study evaluated α-lipoic acid (ALA) as a neuroprotective agent in a rat model of Parkinson’s disease (PD) induced by rotenone. Rotenone exposure led to decreased striatal complex I activity, reduced glutathione levels, increased nitrite concentrations, elevated caspase-3 activity, and ultrastructural neuronal damage, indicative of mitochondrial dysfunction and oxidative

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June 26, 2025 No Comments

Methylene blue prevents neurodegeneration caused by rotenone in the retina

This study explored the neuroprotective effects of methylene blue against retinal neurodegeneration induced by rotenone, a mitochondrial complex I inhibitor. In a mouse model, intravitreal injection of methylene blue was shown to prevent retinal ganglion cell degeneration in a dose-dependent manner. The study demonstrated that methylene blue acts as an

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June 26, 2025 No Comments

Striatal neuroprotection with methylene blue

​This study investigated methylene blue’s (MB) neuroprotective effects in a rat model of striatal damage induced by rotenone (Rot), a mitochondrial toxin. Co-administration of MB significantly reduced the size of Rot-induced lesions, preserved cytochrome oxidase activity, and decreased oxidative stress in the striatum. Additionally, MB maintained functional connectivity in motor

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June 26, 2025 No Comments

L-deprenyl protects against rotenone-induced, oxidative stress-mediated dopaminergic neurodegeneration in rats

This in vivo animal study investigated the neuroprotective effects of L-deprenyl against rotenone-induced dopaminergic neurodegeneration in rats. Rotenone, a mitochondrial complex-I inhibitor, induces oxidative stress and neuronal damage, mimicking Parkinson’s disease pathology. L-deprenyl treatment significantly reduced oxidative stress markers, preserved dopaminergic neurons in the substantia nigra, decreased lipid peroxidation, and

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June 26, 2025 No Comments