Tag: RNA interference

Lipoprotein(a) and Cardiovascular Disease: A Missing Link for Premature Atherosclerotic Heart Disease and/or Residual Risk

This comprehensive review highlights lipoprotein(a) [Lp(a)] as a genetically determined, independent risk factor for various cardiovascular diseases, including coronary artery disease, aortic valve stenosis, ischemic stroke, heart failure, and peripheral arterial disease. Elevated Lp(a) levels (≥50 mg/dL or ≥100 nmol/L) are prevalent in approximately 20% of the population and contribute

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Glutathione depletion and overproduction both initiate degeneration of nigral dopaminergic neurons

This 2011 study investigated how both glutathione (GSH) deficiency and excess affect the viability of nigral dopaminergic neurons, key cells involved in Parkinson’s disease (PD). Using a viral vector-based RNA interference model in rats, researchers modulated the synthesis of GSH by targeting glutamate–cysteine ligase subunits. Both decreased and increased GSH

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