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Tag: reactive carbonyl species

L-carnosine and its Derivatives as New Therapeutic Agents for the Prevention and Treatment of Vascular Complications of Diabetes

This review explores the potential of L-carnosine and its carnosinase-resistant derivatives in preventing and treating vascular complications in diabetes. L-carnosine acts as a scavenger of reactive carbonyl species (RCS), helping to reduce the formation of harmful advanced glycation end-products (AGEs) and advanced lipoxidation end-products (ALEs), both of which contribute to

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June 26, 2025 No Comments

Understanding the antioxidant and carbonyl sequestering activity of carnosine: direct and indirect mechanisms

This review article explores the antioxidant and carbonyl-sequestering activities of carnosine, a naturally occurring dipeptide composed of β-alanine and L-histidine. Carnosine directly neutralizes reactive oxygen species (ROS) and reactive carbonyl species (RCS), forms stable adducts with carbonyl compounds to prevent protein damage, chelates transition metals to inhibit oxidative reactions, and

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June 26, 2025 No Comments