Well Referenced

Tag: Psychiatry

B vitamins to enhance treatment response to antidepressants in middle-aged and older adults: results from the B-VITAGE randomised, double-blind, placebo-controlled trial

This randomized, double-blind, placebo-controlled trial assessed whether adjunctive B vitamin supplementation (0.5 mg B12, 2 mg folic acid, 25 mg B6) enhances antidepressant response in adults aged 50+ with major depression. Over 12 weeks, remission rates were similar between the vitamin and placebo groups. However, at 26 and 52 weeks,

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June 26, 2025 No Comments

B-vitamins in Relation to Depression in Older Adults Over 60 Years of Age: The Trinity Ulster Department of Agriculture (TUDA) Cohort Study

This cross-sectional study of 5,186 adults aged ≥60 years from the TUDA cohort investigated the relationship between B-vitamin status and mental health. Low levels of folate, vitamin B6, and riboflavin—but not B12—were significantly associated with increased risk of depression, as measured by the CES-D scale. Vitamin B6 deficiency was also

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June 26, 2025 No Comments

Dietary intake of B vitamins and their association with depression, anxiety, and stress symptoms: A cross-sectional, population-based survey

This cross-sectional study involving 7,387 Iranian adults aged 20–70 years examined the relationship between dietary B vitamin intake and psychological symptoms. Using a validated food frequency questionnaire and the DASS-21 scale, the study found that higher biotin intake was significantly associated with lower odds of depression (OR 0.71), anxiety (OR

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June 26, 2025 No Comments

Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials

This systematic review analyzed 20 randomized controlled trials involving 2,256 adults diagnosed with major depressive disorder (MDD), generalized anxiety disorder (GAD), or exhibiting depressive/anxiety symptoms. The findings indicate that supplementation with B vitamins (such as folic acid, L-methylfolate, thiamine, and methylcobalamin) and vitamin D, either as monotherapy or adjunctive to

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June 26, 2025 No Comments

Potential Role of Vitamin D for the Management of Depression and Anxiety

This 2019 review article, published in CNS Drugs, explores the potential role of vitamin D in the management of depression and anxiety. The authors discuss the biological mechanisms by which vitamin D may influence mood disorders, including its involvement in neuroimmune modulation, regulation of neurotrophic factors, and impact on neurotransmitter

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June 26, 2025 No Comments