Well Referenced

Tag: proton pump inhibitors

All You Need to Know About Gastrinoma Today: Gastrinoma and Zollinger-Ellison Syndrome – A Thorough Update

This 2023 review provides a comprehensive update on gastrinoma and Zollinger-Ellison syndrome (ZES), neuroendocrine tumors that secrete excessive gastrin leading to gastric acid hypersecretion. The article discusses the pathophysiology, highlighting that gastrinomas are often located within the “gastrinoma triangle” (duodenum, pancreas, and extra-hepatic biliary system) and may be sporadic or

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June 26, 2025 No Comments

Herbal formula improves upper and lower gastrointestinal symptoms and gut health in Australian adults with digestive disorders

This 2020 single-arm, 16-week pre-post study evaluated the NC Gut Relief Formula—a multi-ingredient herbal and nutritional supplement containing curcumin, Aloe vera, slippery elm, guar gum, pectin, peppermint oil, and glutamine—in 43 Australian adults with chronic digestive symptoms. Participants consumed 5 g/day for 4 weeks, then 10 g/day for 4 weeks.

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June 26, 2025 No Comments

Pharmacoepidemiology for Nephrologists: Do Proton Pump Inhibitors Cause Chronic Kidney Disease?

This review critically examines the association between proton pump inhibitor (PPI) use and the development of chronic kidney disease (CKD). Drawing from observational studies and pharmacoepidemiologic data, it highlights potential mechanisms such as acute interstitial nephritis leading to CKD. The article emphasizes the need for cautious PPI prescribing, especially in

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June 26, 2025 No Comments

Proton Pump Inhibitor-Related Gastric Mucosal Changes

This 2019 review explores the spectrum of histological and endoscopic gastric mucosal changes associated with prolonged use of proton pump inhibitors (PPIs). Chronic PPI therapy can lead to morphological alterations such as parietal cell protrusion, cystic dilation of fundic glands, and foveolar hyperplasia. These changes are often visualized endoscopically as

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June 26, 2025 No Comments