probiotics Archives - Well Referenced

Effects of a Diet-Based Weight-Reducing Program with Probiotic Supplementation on Satiety Efficiency, Eating Behaviour Traits, and Psychosocial Behaviours in Obese Individuals

A double-blind, randomized, placebo-controlled trial involving 105 obese adults (45 men, 60 women) assessed the impact of Lactobacillus rhamnosus CGMCC1.3724 (LPR) supplementation over a 24-week period (12 weeks of weight loss followed by 12 weeks of maintenance). Participants consumed two capsules daily, each containing 10 mg of LPR (1.6×10^8 CFU),

June 26, 2025 No Comments

Health supplements for allergic rhinitis: A mixed-methods systematic review

This 2020 mixed-methods systematic review assessed the efficacy and safety of various health supplements in managing allergic rhinitis. Analyzing 48 randomized controlled trials and 10 observational studies, the review found promising evidence for single supplements such as apple polyphenols, tomato extract, spirulina, chlorophyll c2, honey, conjugated linoleic acid, methylsulfonylmethane (MSM),

June 26, 2025 No Comments

Anti-Obesity Effect of Lactobacillus gasseri BNR17 in High-Sucrose Diet-Induced Obese Mice

This 2013 study investigated the effects of Lactobacillus gasseri BNR17, a probiotic strain isolated from human breast milk, on obesity in C57BL/6J mice fed a high-sucrose diet. Over 10 weeks, mice receiving BNR17 (10⁹ or 10¹⁰ CFU/day) exhibited significant reductions in body weight gain and white adipose tissue mass compared

June 26, 2025 No Comments

Intestinal Microbiota; Relevance to Obesity and Modulation by Prebiotics and Probiotics

This 2013 literature review analyzed 61 studies to explore the relationship between intestinal microbiota and obesity, focusing on the effects of prebiotics and probiotics. Findings indicate that obese individuals exhibit distinct gut microbial compositions compared to non-obese individuals, with alterations affecting energy homeostasis, lipid metabolism, and intestinal permeability. Interventions using

June 26, 2025 No Comments

The use of probiotics in healthy volunteers with evacuation disorders and hard stools: a double-blind, randomized, placebo-controlled study

This double-blind, randomized, placebo-controlled study assessed the efficacy of two probiotic blends in managing evacuation disorders and hard stools among 300 healthy volunteers aged 24–71 years. Participants were divided into three groups: Group A received a placebo; Group B received a combination of Lactobacillus plantarum LP01 and Bifidobacterium breve BR03

June 26, 2025 No Comments

Good Bug, Bad Bug: Breaking through Microbial Stereotypes

This 2018 commentary challenges the binary classification of microbes as strictly beneficial or harmful, proposing that microbial roles are highly context-dependent. Using Akkermansia muciniphila as a case study, the authors illustrate how a bacterium commonly linked to metabolic health can also be associated with disease under certain conditions. The article

June 26, 2025 No Comments

Lactobacillus species: taxonomic complexity and controversial susceptibilities

This 2015 review discusses the taxonomic challenges and antibiotic susceptibility controversies surrounding Lactobacillus species. With over 170 species exhibiting phenotypic similarities, accurate identification often requires molecular methods. While generally considered non-pathogenic and used as probiotics, certain strains have been implicated in infections, particularly in immunocompromised individuals. The article highlights the

June 26, 2025 No Comments

Colonic health: fermentation and short chain fatty acids

This 2006 review explores the role of short-chain fatty acids (SCFAs)—primarily acetate, propionate, and butyrate—produced through the fermentation of dietary fibers and resistant starches by colonic microbiota. SCFAs serve as energy sources for colonocytes, regulate colonic pH, and influence systemic metabolic processes. The production of SCFAs is influenced by the

June 26, 2025 No Comments

Chronic constipation: current treatment options

This 2011 review outlines the management strategies for chronic constipation, emphasizing a stepwise approach. Initial interventions include dietary and lifestyle modifications, such as increased fiber intake and physical activity. Pharmacologic treatments encompass bulking agents (e.g., psyllium), stool softeners, osmotic laxatives (e.g., polyethylene glycol), and stimulant laxatives (e.g., bisacodyl). The review

June 26, 2025 No Comments

Recycling Metchnikoff: Probiotics, the Intestinal Microbiome and the Quest for Long Life

This 2013 perspective article revisits the pioneering work of Élie Metchnikoff, who in the early 20th century proposed that health could be enhanced and aging delayed by manipulating the intestinal microbiome with beneficial bacteria found in fermented foods like yogurt. Metchnikoff’s theories, which included concepts such as bacterial translocation and

June 26, 2025 No Comments

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