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Tag: pregnenolone metabolism

Pregnenolone and dehydroepiandrosterone as precursors of native 7-hydroxylated metabolites which increase the immune response in mice

This study investigated the metabolism of dehydroepiandrosterone (DHEA) and pregnenolone (PREG) in various mouse tissues and their effects on immune response. Using deuterium-labeled substrates and gas chromatography-mass spectrometry, researchers identified 7α-hydroxy-DHEA and 5-androstene-3β,17β-diol as DHEA metabolites across all tested tissues, while PREG metabolism was less extensive, with 7α-hydroxy-PREG found in

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June 26, 2025 No Comments

Pregnenolone metabolism in an aldosterone secreting tumor of the adrenal and its adjacent adrenal tissue

This study explores the altered metabolism of pregnenolone in an aldosterone-secreting adrenal tumor and its adjacent adrenal tissue. The findings highlight changes in the steroidogenesis pathways of pregnenolone conversion to aldosterone and other steroid hormones, providing insights into the underlying mechanisms of hyperaldosteronism and adrenal tumors. The results could potentially

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June 26, 2025 No Comments