Well Referenced

Tag: prediabetes

Safety, tolerability and sustained weight loss over 2 years with the once-daily human GLP-1 analog, liraglutide

This 2-year randomized, double-blind, placebo-controlled trial assessed the long-term safety, tolerability, and efficacy of once-daily subcutaneous liraglutide (1.2–3.0 mg) in 564 obese adults (BMI 30–40 kg/m²) across 19 European centers. After a 20-week core phase, 398 participants entered a 2-year extension. At 1 year, those on liraglutide 3.0 mg lost

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June 26, 2025 No Comments

Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline

This 2024 guideline updates the 2011 recommendations, focusing on vitamin D use for disease prevention in individuals without established indications for treatment or 25(OH)D testing. Key recommendations include: (1) Empiric vitamin D supplementation is suggested for children and adolescents aged 1–18 years to prevent nutritional rickets and potentially reduce respiratory

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June 26, 2025 No Comments

Glycemia and Atherosclerotic Cardiovascular Disease: Exploring the Gap Between Risk Marker and Risk Factor

This review examines the relationship between glycemia and atherosclerotic cardiovascular disease (ASCVD), evaluating whether hyperglycemia serves merely as a risk marker or as a causative risk factor. Epidemiological evidence indicates that various glycemic indices (fasting plasma glucose, postprandial glucose, HbA1c) are associated with increased ASCVD risk, even in prediabetic states.

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June 26, 2025 No Comments

Metformin improves putative longevity effectors in peripheral mononuclear cells from subjects with prediabetes. A randomized controlled trial

This randomized, single-blind, placebo-controlled trial evaluated the impact of metformin on longevity-associated pathways in 38 prediabetic individuals over two months. Participants received either metformin (1500 mg/day) or placebo. Metformin treatment led to significant improvements in metabolic parameters and insulin sensitivity. Notably, there was an increase in SIRT1 gene and protein

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June 26, 2025 No Comments

Association of Lipoprotein and Apolipoprotein Ratios With Glycemic Levels in Individuals With Prediabetes: A Case-Control Study

This case-control study published in Cureus investigates the relationship between lipoprotein and apolipoprotein ratios and glycemic levels in individuals with prediabetes. The study involved 150 participants, including 75 individuals with prediabetes and 75 healthy controls. It found that prediabetic individuals had significantly higher levels of lipoprotein(a), the ApoB/ApoA1 ratio, and

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June 26, 2025 No Comments

Dietary Supplementation with Inulin Modulates the Gut Microbiota and Improves Insulin Sensitivity in Prediabetes

This 2021 observational study published in the International Journal of Endocrinology (PMID: 34257649) investigated the effects of inulin supplementation on insulin sensitivity and gut microbiota in individuals with prediabetes. Over six months, 49 participants consumed 15 g of inulin daily, resulting in significant improvements in insulin sensitivity, with reductions in

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June 26, 2025 No Comments

Testosterone Therapy in Men With Hypogonadism Prevents Progression From Prediabetes to Type 2 Diabetes: Eight-Year Data From a Registry Study

This study examined the effects of testosterone therapy (TTh) in men with hypogonadism and prediabetes over an 8-year period. The findings indicated that TTh significantly improved metabolic parameters, including HbA1c, fasting glucose, and lipid profiles. Men receiving TTh had a 0.39% decrease in HbA1c, while controls saw a 0.63% increase.

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June 26, 2025 No Comments