This 1987 prospective cohort study, published in The New England Journal of Medicine, assessed the impact of prenatal and postnatal lead exposure on early cognitive development in 249 children from birth to two years of age. Researchers categorized infants into three prenatal exposure groups based on umbilical cord blood lead
In this 2022 review, Guerini et al. examine the multifaceted role of N-acetylcysteine (NAC) in the management of cystic fibrosis (CF). NAC, known for its mucolytic and antioxidant properties, is explored for its potential to alleviate CF symptoms by reducing mucus viscosity and oxidative stress. The authors discuss various administration
In this pivotal 2017 study published in the New England Journal of Medicine, Shi et al. investigate the link between NAD+ deficiency and congenital malformations. Through genomic sequencing of families with multiple congenital anomalies, the researchers identified loss-of-function mutations in the HAAO and KYNU genes, which are integral to the
This 2021 study by Szot et al. presents new cases that broaden the understanding of Congenital NAD Deficiency Disorder (CNDD), a rare autosomal recessive condition resulting from mutations in the NAXE gene. The authors describe patients exhibiting a spectrum of clinical features, including developmental delay, hypotonia, seizures, and brain abnormalities.
This phase I dose-escalation study evaluated the safety and pharmacokinetics of intravenous zinc supplementation in critically ill pediatric patients. Conducted at a single center, the study enrolled 10 children aged 1–17 years with systemic inflammatory response syndrome (SIRS) or sepsis. Participants received escalating doses of intravenous zinc chloride (0.25, 0.5,
This 2015 double-blind, randomized, placebo-controlled pilot study evaluated the efficacy of a probiotic consortium (Lab4) combined with vitamin C in preventing respiratory tract infections (RTIs) among 69 healthy preschool children aged 3–6 years. Over six months, children received either a daily dose of 1.25 × 10¹⁰ CFU of specific Lactobacillus
