This 2011 study by Cahill et al., published in the American Journal of Obstetrics and Gynecology, employed a decision-analytic and cost-effectiveness model to evaluate the use of magnesium sulfate (MgSO₄) for neuroprotection in women at risk of preterm birth before 32 weeks’ gestation. The model compared MgSO₄ therapy to no
This prospective cohort study, conducted in northeastern Oklahoma, assessed the impact of prenatal manganese (Mn) exposure on early childhood neurodevelopment among residents living near a mining-impacted Superfund site. Researchers measured Mn concentrations in maternal and umbilical cord blood samples and evaluated children’s neurodevelopmental outcomes at 12 and 24 months using
This 2021 observational study, published in Environmental International, utilized data from the National Children’s Study to assess the impact of prenatal exposure to multiple metals on birth outcomes. Researchers measured concentrations of various metals, including arsenic, cadmium, lead, and mercury, in maternal blood samples collected during pregnancy. The study found
This prospective cohort study, conducted in Zhejiang Province, China, examined the effects of prenatal exposure to organophosphate (OP) insecticides on infant sensory development. Researchers measured concentrations of 30 OPs in umbilical cord blood using gas chromatography-tandem mass spectrometry. Infant sensory functions were assessed through grating visual acuity (VA) and auditory
This prospective cohort study, conducted in Mexico City and published in Environmental Health Perspectives (2006), examined the impact of prenatal lead exposure on children’s intellectual development. Researchers measured maternal blood lead levels during pregnancy and assessed children’s IQ scores between ages 6 and 10. The study found a significant inverse
This study, conducted within the PROGRESS birth cohort in Mexico City, examined the relationship between prenatal lead exposure and mitochondrial DNA (mtDNA) content in cord blood. Researchers measured lead levels in maternal blood during pregnancy and in umbilical cord blood at birth, alongside assessing mtDNA content in cord blood leukocytes.
This study, published in Environmental Research in 2013, investigated the association between low-level prenatal lead exposure and birth outcomes. Researchers measured maternal and cord blood lead levels and examined their relationships with birth weight, length, and head circumference. The findings indicated that even low levels of lead exposure during pregnancy
This 2018 review article in Nutrients explores strategies to mitigate the neurodevelopmental consequences of early-life iron deficiency (ID) in children. The authors discuss the critical role of iron in brain development, particularly during the prenatal and early postnatal periods, and how ID during these stages can lead to long-term cognitive
This cross-sectional study, conducted at Mousavi Hospital in Zanjan, Iran, assessed the association between maternal and neonatal blood lead levels and neonatal anthropometric outcomes. Seventy pregnant women and their newborns were enrolled, with lead concentrations measured in maternal and umbilical cord blood samples. The mean maternal blood lead level was
This study, published in Environmental International (2017), investigates racial disparities in lead exposure by analyzing deciduous teeth from 94 children in Detroit, Michigan. Utilizing laser ablation-inductively coupled plasma mass spectrometry, researchers measured lead concentrations in prenatal and early postnatal dentine layers. Findings revealed that African-American children had significantly higher lead
