Pediatrics Archives - Well Referenced

Lead, mercury and cadmium in umbilical cord blood and its association with parental epidemiological variables and birth factors

This 2013 cross-sectional biomonitoring study from Spain, published in BMC Public Health, analyzed blood concentrations of lead, mercury, and cadmium in 145 newborn–mother–father trios as part of the BioMadrid Project. The geometric mean concentrations in cord blood were 14.09 μg/L for lead, 6.72 μg/L for mercury, and 0.27 μg/L for

June 26, 2025 No Comments

Longitudinal analyses of prenatal and postnatal lead exposure and early cognitive development

This 1987 prospective cohort study, published in The New England Journal of Medicine, assessed the impact of prenatal and postnatal lead exposure on early cognitive development in 249 children from birth to two years of age. Researchers categorized infants into three prenatal exposure groups based on umbilical cord blood lead

June 26, 2025 No Comments

Low-level prenatal lead exposure and infant sensory function

In this 2016 prospective cohort study conducted in rural northeastern China, researchers investigated the impact of prenatal lead exposure on infant sensory development, focusing on auditory and visual systems. Maternal blood lead levels were measured during mid- and late pregnancy, and umbilical cord blood was collected at birth. Auditory brainstem

June 26, 2025 No Comments

Magnesium chloride Pregnancy and Breastfeeding Warnings

Magnesium chloride is classified as a pregnancy category C drug by the FDA, indicating that risk to the fetus cannot be ruled out. There is a lack of adequate and well-controlled studies in pregnant women; therefore, it should be used during pregnancy only if clearly needed. Some authorities advise against

June 26, 2025 No Comments

Magnesium sulfate therapy for the prevention of cerebral palsy in preterm infants: a decision-analytic and economic analysis

This 2011 study by Cahill et al., published in the American Journal of Obstetrics and Gynecology, employed a decision-analytic and cost-effectiveness model to evaluate the use of magnesium sulfate (MgSO₄) for neuroprotection in women at risk of preterm birth before 32 weeks’ gestation. The model compared MgSO₄ therapy to no

June 26, 2025 No Comments

Maternal and Cord Blood Manganese Concentrations and Early Childhood Neurodevelopment among Residents near a Mining-Impacted Superfund Site

This prospective cohort study, conducted in northeastern Oklahoma, assessed the impact of prenatal manganese (Mn) exposure on early childhood neurodevelopment among residents living near a mining-impacted Superfund site. Researchers measured Mn concentrations in maternal and umbilical cord blood samples and evaluated children’s neurodevelopmental outcomes at 12 and 24 months using

June 26, 2025 No Comments

Prenatal exposure to multiple metals and birth outcomes: An observational study within the National Children’s Study cohort

This 2021 observational study, published in Environmental International, utilized data from the National Children’s Study to assess the impact of prenatal exposure to multiple metals on birth outcomes. Researchers measured concentrations of various metals, including arsenic, cadmium, lead, and mercury, in maternal blood samples collected during pregnancy. The study found

June 26, 2025 No Comments

Prenatal organophosphate insecticide exposure and infant sensory function

This prospective cohort study, conducted in Zhejiang Province, China, examined the effects of prenatal exposure to organophosphate (OP) insecticides on infant sensory development. Researchers measured concentrations of 30 OPs in umbilical cord blood using gas chromatography-tandem mass spectrometry. Infant sensory functions were assessed through grating visual acuity (VA) and auditory

June 26, 2025 No Comments

Reduced intellectual development in children with prenatal lead exposure

This prospective cohort study, conducted in Mexico City and published in Environmental Health Perspectives (2006), examined the impact of prenatal lead exposure on children’s intellectual development. Researchers measured maternal blood lead levels during pregnancy and assessed children’s IQ scores between ages 6 and 10. The study found a significant inverse

June 26, 2025 No Comments

Altered cord blood mitochondrial DNA content and pregnancy lead exposure in the PROGRESS cohort

This study, conducted within the PROGRESS birth cohort in Mexico City, examined the relationship between prenatal lead exposure and mitochondrial DNA (mtDNA) content in cord blood. Researchers measured lead levels in maternal blood during pregnancy and in umbilical cord blood at birth, alongside assessing mtDNA content in cord blood leukocytes.

June 26, 2025 No Comments

Tag: Pediatrics