Well Referenced

Tag: Nutritional Supplementation

Kynurenine Pathway Pathologies: Do Nicotinamide and Other Pathway Co-Factors Have a Therapeutic Role in Reduction of Symptom Severity, Including Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FM)

This review explores the role of the kynurenine pathway in the pathophysiology of CFS and FM, highlighting how its dysregulation, often due to chronic inflammation, leads to tryptophan depletion and neuroimmune disturbances. The author suggests that deficiencies in nicotinamide and other cofactors, resulting from an overactive kynurenine pathway, may exacerbate

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June 26, 2025 No Comments

Mitochondrial Dysfunction and Neurodegenerative Disorders: Role of Nutritional Supplementation

This systematic review examines the role of mitochondrial dysfunction in various neurodegenerative diseases—such as Parkinson’s disease, Alzheimer’s disease, ALS, multiple system atrophy, and progressive supranuclear palsy—and explores the potential benefits of nutritional supplementation with CoQ10, B-vitamins/NADH, L-carnitine, vitamin D, and alpha-lipoic acid. These nutrients are proposed to support mitochondrial ATP

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June 26, 2025 No Comments

Review: A systematic review of the effects of functional amino acids on small intestine barrier function and immunity in piglets

This systematic review evaluates the effects of functional amino acids—specifically L-Arginine, L-Glutamine, and L-Glutamate—on gut barrier function and immune health in post-weaning piglets. The findings suggest that supplementing these amino acids beyond standard nutritional requirements enhances gut morphology, tight junction integrity, and immune response, especially during the stressful weaning period.

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June 26, 2025 No Comments

Assessment of adverse reactions to α-lipoic acid containing dietary supplements through spontaneous reporting systems

The study titled “Assessment of adverse reactions to α-lipoic acid containing dietary supplements through spontaneous reporting systems” (Clinical Nutrition, 2021, PMID: 32778460) is an observational study analyzing 116 reports of adverse reactions (ARs) to α-lipoic acid (ALA) supplements collected by the Italian Phytovigilance System from 2002 to 2020. The majority

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June 26, 2025 No Comments