Kynurenine Pathway Pathologies: Do Nicotinamide and Other Pathway Co-Factors Have a Therapeutic Role in Reduction of Symptom Severity, Including Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FM)

This review explores the role of the kynurenine pathway in the pathophysiology of CFS and FM, highlighting how its dysregulation, often due to chronic inflammation, leads to tryptophan depletion and neuroimmune disturbances. The author suggests that deficiencies in nicotinamide and other cofactors, resulting from an overactive kynurenine pathway, may exacerbate