Well Referenced

Tag: Nephrology

Pharmacoepidemiology for Nephrologists: Do Proton Pump Inhibitors Cause Chronic Kidney Disease?

This review critically examines the association between proton pump inhibitor (PPI) use and the development of chronic kidney disease (CKD). Drawing from observational studies and pharmacoepidemiologic data, it highlights potential mechanisms such as acute interstitial nephritis leading to CKD. The article emphasizes the need for cautious PPI prescribing, especially in

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June 26, 2025 No Comments

NAD+ Homeostasis in Diabetic Kidney Disease

This review by Xu, Kitada, and Koya (2021) explores the intricate relationship between nicotinamide adenine dinucleotide (NAD+) homeostasis and diabetic kidney disease (DKD). NAD+, a vital coenzyme in redox reactions, is crucial for mitochondrial function and cellular metabolism. In DKD, hyperglycemia-induced oxidative stress and inflammation disrupt NAD+ levels, impairing renal

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June 26, 2025 No Comments

Current findings on the efficacy of incretin-based drugs for diabetic kidney disease: A narrative review

This 2023 narrative review by Mima et al. explores the potential renoprotective effects of incretin-based therapies—specifically GLP-1 receptor agonists and DPP-4 inhibitors—in managing diabetic kidney disease (DKD), a leading cause of chronic kidney disease and end-stage renal disease. The authors discuss how GLP-1 receptor agonists may exert vasotropic actions that

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June 26, 2025 No Comments

Supplemental Nutrients for Prevention of Vascular Calcification in Patients with Chronic Kidney Disease

This 2019 review article, published in Nutrients, explores the potential role of specific nutrients in preventing vascular calcification (VC) among patients with chronic kidney disease (CKD). The authors discuss the pathophysiology of VC in CKD, highlighting the imbalance between promoters and inhibitors of calcification due to disrupted mineral metabolism. The

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June 26, 2025 No Comments