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Tag: Multiple Myeloma

Lymphoma and myeloma cells are highly sensitive to growth arrest and apoptosis induced by artesunate

This 2013 study evaluated the antitumor effects of artesunate, an antimalarial drug, on multiple myeloma and diffuse large B-cell lymphoma (DLBCL) cell lines. Artesunate treatment effectively inhibited cell proliferation and induced apoptosis in these cell lines. The apoptotic response was associated with downregulation of MYC and anti-apoptotic Bcl-2 family proteins,

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June 26, 2025 No Comments

Artesunate overcomes drug resistance in multiple myeloma by inducing mitochondrial stress and non-caspase apoptosis

This study examines how artesunate overcomes drug resistance in multiple myeloma cells by inducing mitochondrial stress and non-caspase-dependent apoptosis. The findings suggest that artesunate disrupts mitochondrial function, leading to cell death independent of the traditional caspase pathway. These results highlight artesunate as a potential therapeutic agent to bypass common mechanisms

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June 26, 2025 No Comments