Well Referenced

Tag: mTORC1

Role of Branched-Chain Amino Acid Metabolism in Type 2 Diabetes, Obesity, Cardiovascular Disease and Non-Alcoholic Fatty Liver Disease

This 2022 review article examines the role of branched-chain amino acids (BCAAs)—leucine, isoleucine, and valine—in metabolic health and disease. Elevated BCAA levels are linked to insulin resistance, type 2 diabetes, obesity, cardiovascular disease, and non-alcoholic fatty liver disease (NAFLD). BCAAs activate the mTORC1 pathway, influencing cell growth and glucose metabolism.

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June 26, 2025 No Comments

The Role of the Mammalian Target of Rapamycin (mTOR) in Pulmonary Fibrosis

This 2018 review examines the role of the PI3K/AKT/mTOR pathway in the development and progression of pulmonary fibrosis, particularly idiopathic pulmonary fibrosis (IPF) and radiation-induced pulmonary fibrosis (RIPF). It outlines how mTOR dysregulation contributes to fibroblast proliferation, suppression of autophagy, chronic inflammation, and epithelial-mesenchymal transition (EMT), all of which drive

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June 26, 2025 No Comments