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Tag: mouse model

LPS induces microglial activation and GABAergic synaptic deficits in the hippocampus accompanied by prolonged cognitive impairment

This 2023 in vivo animal study published in Scientific Reports (DOI: 10.1038/s41598-023-32798-9) explored how systemic inflammation induced by lipopolysaccharide (LPS) affects microglial activation, synaptic function, and cognition. Using a mouse model, researchers found that microglial activation peaked 3 days after LPS injection and was followed by GABAergic synaptic impairments and

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June 26, 2025 No Comments

Hepatic phosphatidylcholine catabolism driven by PNPLA7 and PNPLA8 supplies endogenous choline to replenish the methionine cycle with methyl groups

This in vitro and animal study explored the role of the PNPLA8-PNPLA7 enzymatic axis in hepatic phosphatidylcholine (PC) catabolism and its impact on methyl group metabolism. The study found that PNPLA7-deficient and PNPLA8-deficient mice exhibited decreased hepatic glycerophosphocholine (GPC), choline, and methionine cycle metabolites, leading to metabolic imbalances such as

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June 26, 2025 No Comments

Chronic administration of synthetic cannabidiol induces antidepressant effects involving modulation of serotonin and noradrenaline levels in the hippocampus

This study examined the antidepressant-like effects of chronic administration of synthetic cannabidiol (CBD) in mice. Over seven days, mice received CBD at doses of 10, 30, or 100 mg/kg, and depressive-like behaviors were assessed using the forced swim test (FST). The study found that 100 mg/kg of CBD significantly reduced

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June 26, 2025 No Comments