Well Referenced

Tag: mortality

Does growth hormone replacement therapy reduce mortality in adults with growth hormone deficiency? Data from the Dutch National Registry of Growth Hormone Treatment in adults

This nationwide cohort study from the Netherlands analyzed the impact of growth hormone (GH) replacement therapy on mortality in adults with GH deficiency (GHD). The study included 2,229 GH-treated patients, 109 untreated patients, and 356 partially treated patients. Results showed that GH-treated men had mortality rates comparable to the general

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June 26, 2025 No Comments

Socioeconomic factors do not but GH treatment does affect mortality in adult-onset growth hormone deficiency

This nationwide registry study from Denmark investigated the impact of socioeconomic factors and growth hormone (GH) treatment on mortality in adults with adult-onset GH deficiency. The study included 276 patients with GH deficiency and 25,717 matched controls. Results indicated that GH-treated patients exhibited reduced all-cause and malignancy-related mortality compared to

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June 26, 2025 No Comments

Long-term safety of growth hormone—a combined registry analysis

This comprehensive analysis reviewed data from multiple growth hormone (GH) registries to assess the long-term safety of GH treatment in children and adults. The study found no increased risk of mortality, stroke, or new malignancies in GH-treated individuals without pre-existing risk factors. However, an elevated risk of secondary neoplasms was

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June 26, 2025 No Comments

hsCRP Level and the Risk of Death or Recurrent Cardiovascular Events in Patients With Myocardial Infarction: a Healthcare-Based Study

This observational study of 17,464 myocardial infarction survivors found that elevated high-sensitivity C-reactive protein (hsCRP) levels were associated with higher risks of all-cause mortality and major adverse cardiovascular events. Patients with hsCRP levels ≥2 mg/L or >3 mg/L faced a significantly increased hazard ratio for these outcomes. By identifying individuals

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June 26, 2025 No Comments

Long-term Host Immune Response Trajectories Among Hospitalized Patients With Sepsis

This 2019 prospective cohort study published in JAMA Network Open (PMID: 31390038) analyzed long-term immune response trajectories in 483 sepsis survivors across 12 U.S. hospitals. Researchers tracked biomarkers of inflammation (hs-CRP) and immunosuppression (sPD-L1) over 12 months and identified two phenotypes: one with persistent hyperinflammation and immunosuppression, and another with

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June 26, 2025 No Comments

Blood fibrinogen as a biomarker of chronic obstructive pulmonary disease

This study published in Thorax explores the role of blood fibrinogen as a biomarker in chronic obstructive pulmonary disease (COPD). The review suggests that fibrinogen levels are significantly associated with COPD presence, exacerbation frequency, and mortality risk, making it a potential biomarker for risk stratification. However, fibrinogen does not predict

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June 26, 2025 No Comments

Statins for primary prevention of cardiovascular events and mortality in old and very old adults with and without type 2 diabetes: retrospective cohort study

This retrospective cohort study analyzed data from 46,864 individuals aged 75 and older without clinically recognized atherosclerotic cardiovascular disease (CVD) to evaluate the impact of statin therapy on primary prevention. Over a median follow-up of 5.6 years, statin use did not significantly reduce CVD events or all-cause mortality in those

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June 26, 2025 No Comments

Ascertaining cause of death among men in the prostate cancer intervention versus observation trial

This study from the Prostate Cancer Intervention Versus Observation Trial (PIVOT) assessed cause-of-death determinations in men with localized prostate cancer, comparing the accuracy of death certificates against committee adjudications. It was found that death certificates had low initial agreement with committee reviews, improving after combining certain categories, but still showed

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June 26, 2025 No Comments