This review article explores the immunological alterations associated with frailty in older adults. Frailty is characterized by a heightened inflammatory state, evidenced by elevated serum levels of interleukin-6 (IL-6) and C-reactive protein (CRP), and an increased number of circulating monocytes. These changes reflect a chronic, low-grade inflammation known as “inflammaging.”
This in vitro study examined the effects of Viscum album (mistletoe) lipophilic extract on the polarization and function of monocytes/macrophages derived from tumor cells. The research found that mistletoe extract significantly modulated immune cell functions, potentially enhancing the immune system’s ability to target and destroy cancer cells. While the study’s
This study investigates the effects of [norleucine27]growth hormone-releasing hormone (GHRH) (1-29)-NH2 on immune function in elderly adults. Conducted as a single-blind, randomized, placebo-controlled trial, it involved 19 healthy elderly participants (10 women, 9 men) receiving nightly subcutaneous injections of either placebo or GHRH analog for 16 weeks. The results demonstrated
