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Tag: monoamine oxidase inhibition

Role of monoamine oxidase, nitric oxide synthase and regional brain monoamines in the antidepressant-like effects of methylene blue and selected structural analogues

This animal study evaluated the antidepressant-like effects of methylene blue (MB) and its analogues, methylene green (MG) and others, demonstrating significant reductions in depressive behaviors in rodents. MB and MG showed dose-dependent improvements in depression symptoms, primarily by enhancing mitochondrial function, inhibiting monoamine oxidase (MAO) and nitric oxide synthase (NOS),

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June 26, 2025 No Comments

Cellular and molecular actions of Methylene Blue in the nervous system

Methylene blue (MB) has demonstrated potential therapeutic benefits in neuroprotection, mood disorders, and neurodegenerative diseases such as Alzheimer’s. This review highlights MB’s mechanisms of action, including its inhibition of monoamine oxidase A (MAO-A), which increases serotonin and dopamine levels, and its modulation of the cyclic guanosine monophosphate (cGMP) pathway, which

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June 26, 2025 No Comments

Methylene Blue Analogues with Marginal Monoamine Oxidase Inhibition Retain Antidepressant-like Activity

This study investigated five newly synthesized methylene blue (MB) analogues with low monoamine oxidase A (MAO-A) inhibitory activity to assess their antidepressant-like effects. In rats, these analogues exhibited significant antidepressant effects in the forced swim test (FST), similar to imipramine and MB, without affecting locomotor activity. Their IC₅₀ values for

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June 26, 2025 No Comments