Well Referenced

Tag: minocycline

Same Exposure but Two Radically Different Responses to Antibiotics: Resilience of the Salivary Microbiome versus Long-Term Microbial Shifts in Feces

This 2015 randomized, placebo-controlled study assessed how four common antibiotics (clindamycin, ciprofloxacin, amoxicillin, minocycline) affect the oral and gut microbiota in 66 healthy adults over a year. The study found that the salivary microbiome displayed high resilience, quickly reverting to baseline after antibiotic exposure. In contrast, the fecal microbiome exhibited

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June 26, 2025 No Comments

Tetracyclines and neuromuscular disorders

This 2012 review examines the therapeutic potential of tetracyclines, specifically minocycline and doxycycline, in the treatment of neuromuscular disorders. Tetracyclines possess anti-inflammatory, antioxidant, and anti-apoptotic effects, acting through mechanisms such as microglial inhibition, suppression of oxidative stress, and modulation of mitochondrial function. Preclinical studies have shown promising effects in models

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June 26, 2025 No Comments

Estrogen and estrogen-androgen replacement in postmenopausal women dissatisfied with estrogen-only therapy. Sexual behavior and neuroendocrine responses

This randomized controlled pilot study evaluated the efficacy and tolerability of minocycline 100 mg taken twice daily over 6 months in 40 patients with active rheumatoid arthritis (aged 30–70 years) who met the ACR criteria and had moderate disease activity. The study found that minocycline significantly reduced tender joint counts

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June 26, 2025 No Comments