This review discusses the potential of circulating epigenetic biomarkers, such as methylated DNA and microRNAs, in the early detection and management of lung cancer and malignant mesothelioma. It highlights the limitations of current diagnostic methods and emphasizes the promise of liquid biopsy techniques in improving early diagnosis and treatment monitoring.
This 2017 review discusses the roles of resveratrol (RES), curcumin (CUR), and berberine (BBR) in modulating aging, cancer progression, cancer stem cells (CSCs), and microRNA (miR) expression. RES activates sirtuins (e.g., SIRT1), influencing aging and cancer-related pathways. CUR exhibits anti-inflammatory and anti-cancer properties, particularly against CSCs, by affecting gene methylation
This 2022 review published in the International Journal of Molecular Sciences (DOI: 10.3390/ijms232012671) explores how lipopolysaccharides (LPSs) from Gram-negative gut bacteria contribute to the pathogenesis of Alzheimer’s disease (AD). The article details how LPSs can translocate into systemic circulation through compromised gut and blood-brain barriers—especially in aging or those with
This review explores the role of neuroinflammation in Alzheimer’s disease (AD) and the potential therapeutic application of anti-inflammatory agents. It highlights how astrocytes, microglia, peripheral immune cells, and microRNAs contribute to neuroinflammatory responses that exacerbate AD progression. Anti-inflammatory drugs may offer neuroprotection by modulating these pathways, potentially slowing disease progression
