Well Referenced

Tag: methylation

Quantitative and Qualitative Analysis of Circulating Cell-Free DNA Can Be Used as an Adjuvant Tool for Prostate Cancer Screening: A Meta-Analysis

This 2018 meta-analysis evaluates the diagnostic utility of circulating cell-free DNA (cfDNA) in prostate cancer screening. Analyzing data from multiple studies, the research assesses both quantitative (cfDNA concentration) and qualitative (integrity, methylation patterns) aspects of cfDNA. The findings suggest that cfDNA analysis, particularly when combining quantitative and qualitative measures, can

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June 26, 2025 No Comments

Clinical validation of a targeted methylation-based multi-cancer early detection test using an independent validation set

This clinical validation study evaluated a blood-based multi-cancer early detection (MCED) test that analyzes cell-free DNA (cfDNA) methylation patterns using targeted sequencing and machine learning. Conducted as part of the CCGA study, the analysis included 4,077 participants (2,823 with cancer, 1,254 without). The test achieved a specificity of 99.5% and

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June 26, 2025 No Comments

Methionine Restriction and Cancer Biology

This review discusses the potential benefits of methionine restriction as a therapeutic approach in cancer treatment. It explains how reducing methionine intake inhibits cancer cell growth by limiting methylation, polyamine synthesis, and glutathione formation, all critical processes for tumor growth. Methionine restriction may enhance the efficacy of chemotherapy and offers

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June 26, 2025 No Comments

Combination Methionine-methylation-axis Blockade: A Novel Approach to Target the Methionine Addiction of Cancer

This review discusses the potential benefits of combining methionine restriction with methylation-axis blockade to target methionine addiction in cancer cells. By inhibiting methionine metabolism and blocking methylation processes, this approach reduces tumor growth and enhances the effectiveness of existing cancer treatments. The combination strategy holds promise for improving cancer therapy,

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June 26, 2025 No Comments

The sulfur-containing amino acids: an overview

This review article discusses the roles of sulfur-containing amino acids—methionine, cysteine, homocysteine, and taurine—in human biochemistry. Methionine, an essential amino acid, is involved in methylation reactions and protein synthesis, while cysteine plays a crucial role in protein structure and is the precursor for glutathione and taurine. The metabolism of homocysteine,

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June 26, 2025 No Comments

Genetic impairments in folate enzymes increase dependence on dietary choline for phosphatidylcholine production at the expense of betaine synthesis

This randomized controlled trial investigated how genetic variations in folate-metabolizing enzymes (MTHFR, MTR, MTRR, and MTHFD1) influence choline metabolism in women, assessing whether higher choline intake could mitigate these effects. Women with genetic impairments in folate metabolism showed increased reliance on dietary choline for phosphatidylcholine (PC) synthesis, reducing availability for

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June 26, 2025 No Comments

Nutritional genomics: defining the dietary requirement and effects of choline

This review article explores how genetic variations affect choline metabolism and dietary requirements. It highlights that men and postmenopausal women are more likely to experience liver or muscle dysfunction when deprived of dietary choline, while premenopausal women may resist choline deficiency due to estrogen-induced expression of the PEMT gene, which

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June 26, 2025 No Comments

Roles and Mechanisms of Choline Metabolism in Nonalcoholic Fatty Liver Disease and Cancers

This systematic review explores the role of choline metabolism in nonalcoholic fatty liver disease (NAFLD) and liver cancer, highlighting its key pathways: oxidation, phosphorylation, and acetylation. Choline’s oxidation produces betaine, which aids in methylation and epigenetic regulation, while phosphorylation impacts lipid metabolism and transport. Acetylation results in the formation of

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June 26, 2025 No Comments