Well Referenced

Tag: metal chelation

Understanding the antioxidant and carbonyl sequestering activity of carnosine: direct and indirect mechanisms

This review article explores the antioxidant and carbonyl-sequestering activities of carnosine, a naturally occurring dipeptide composed of β-alanine and L-histidine. Carnosine directly neutralizes reactive oxygen species (ROS) and reactive carbonyl species (RCS), forms stable adducts with carbonyl compounds to prevent protein damage, chelates transition metals to inhibit oxidative reactions, and

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June 26, 2025 No Comments

Decrypting the potential role of α-lipoic acid in Alzheimer’s disease

The article titled “Decrypting the potential role of α-lipoic acid in Alzheimer’s disease” (Life Sciences, 2021, PMID: 34450170) reviews the neuroprotective effects of alpha-lipoic acid (α-LA) in Alzheimer’s disease (AD), which is characterized by amyloid-β plaques, tau protein accumulation, oxidative stress, and mitochondrial dysfunction. The review highlights α-LA’s antioxidant, antiapoptotic,

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June 26, 2025 No Comments

Lipoic acid induces p53-independent cell death in colorectal cancer cells and potentiates the cytotoxicity of 5-fluorouracil

This in vitro study, published in Archives of Toxicology (2015, PMID: 25526924), examined the effects of alpha-lipoic acid (LA) on colorectal cancer (CRC) cells, demonstrating that LA induces cell death regardless of p53 status and enhances the cytotoxic effects of 5-fluorouracil (5-FU). Conducted on various CRC cell lines, the study

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June 26, 2025 No Comments