Well Referenced

Tag: metabolism

Growth hormone administration stimulates energy expenditure and extrathyroidal conversion of thyroxine to triiodothyronine in a dose-dependent manner and suppresses circadian thyrotrophin levels: studies in GH-deficient adults

The study “Growth hormone administration stimulates energy expenditure and extrathyroidal conversion of thyroxine to triiodothyronine in a dose-dependent manner and suppresses circadian thyrotrophin levels: studies in GH-deficient adults” examines the effects of growth hormone (GH) therapy on metabolic processes and thyroid function in adults with GH deficiency. The findings indicate

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June 26, 2025 No Comments

Hypogonadism, ADAM, and hormone replacement

This review article discusses male hypogonadism, or testosterone deficiency syndrome (TDS), a condition characterized by inadequate testosterone production, leading to symptoms such as fatigue, erectile dysfunction, cognitive changes, and altered body composition. It classifies hypogonadism into primary (e.g., genetic disorders like Klinefelter’s syndrome) and secondary causes (e.g., hypothalamic or pituitary

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June 26, 2025 No Comments

Early Life Interventions Can Shape Aging

This study investigates the impact of early-life hormonal interventions on aging using Ames dwarf mice, which are growth hormone (GH) deficient and exhibit extended lifespans. GH injections administered twice daily from two to eight weeks of age normalized several metabolic traits associated with longevity, suggesting that early-life GH therapy may

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June 26, 2025 No Comments

Effect of testosterone on muscle mass and muscle protein synthesis

This study examined the effect of testosterone on muscle mass and protein synthesis. The results showed that testosterone administration led to a significant reduction in leucine oxidation by 17%, indicating enhanced muscle protein synthesis. However, there were no significant changes in whole-body protein synthesis or muscle fiber diameter. These findings

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June 26, 2025 No Comments

NAD⁺ and Sirtuins in Aging and Disease

This review explores the role of nicotinamide adenine dinucleotide (NAD⁺) and sirtuins in aging and disease, highlighting how declining NAD⁺ levels impair nuclear and mitochondrial function, contributing to age-related conditions such as neurodegenerative diseases. NAD⁺ is a critical coenzyme in redox reactions and regulates enzymes involved in metabolism, circadian rhythms,

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June 26, 2025 No Comments