This review article discusses the roles of sulfur-containing amino acids—methionine, cysteine, homocysteine, and taurine—in human biochemistry. Methionine, an essential amino acid, is involved in methylation reactions and protein synthesis, while cysteine plays a crucial role in protein structure and is the precursor for glutathione and taurine. The metabolism of homocysteine,
The 2015 article “Modulation of Metabolic Detoxification Pathways Using Foods and Food-Derived Components: A Scientific Review with Clinical Application” (Journal of Nutrition and Metabolism, PMID: 26167297) reviews how various foods and nutrients influence the body’s detoxification systems, particularly phase I cytochrome P450 enzymes, phase II conjugation enzymes, Nrf2 signaling, and
This article explores the biochemistry of Coenzyme Q (CoQ) biosynthesis, a crucial redox-active lipid essential for mitochondrial function, electron transport, and oxidative phosphorylation. Despite its importance, the complete biosynthetic pathway remains undefined, with several enzymatic steps and molecular functions of key proteins still unclear. Recent advancements using traditional biochemistry and
This study investigated the metabolism of dehydroepiandrosterone (DHEA) and pregnenolone (PREG) in various mouse tissues and their effects on immune response. Using deuterium-labeled substrates and gas chromatography-mass spectrometry, researchers identified 7α-hydroxy-DHEA and 5-androstene-3β,17β-diol as DHEA metabolites across all tested tissues, while PREG metabolism was less extensive, with 7α-hydroxy-PREG found in
The article “Impact of metabolism on the safety of estrogen therapy” (Annals of the New York Academy of Sciences, 2005, PMID: 16024767) examines the metabolic pathways of estrogens used in hormone therapy, emphasizing the formation of catechol estrogens and their oxidation into quinones, which can lead to oxidative stress and
