Well Referenced

Tag: Mendelian randomization

The Impact of Plasma Vitamin C Levels on the Risk of Cardiovascular Diseases and Alzheimer’s Disease: A Mendelian Randomization Study

This 2021 Mendelian randomization study assessed the causal relationship between plasma vitamin C levels and the risk of nine cardiovascular diseases (CVDs) and Alzheimer’s disease (AD). Utilizing 11 single-nucleotide polymorphisms (SNPs) associated with plasma vitamin C levels from a genome-wide meta-analysis (N = 52,018), the researchers performed analyses using fixed-effects

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June 26, 2025 No Comments

Diabetes Secondary to Treatment with Statins

This 2017 review article examines the association between statin therapy and the risk of developing type 2 diabetes mellitus (T2DM). It synthesizes data from population-based studies, randomized clinical trials, mechanistic metabolic studies, and Mendelian randomization analyses. Statins were associated with a 9%–12% increased risk of diabetes in randomized controlled trials

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June 26, 2025 No Comments

Association between the oxidative balance score and thyroid function: Results from the NHANES 2007-2012 and Mendelian randomization study

This cross-sectional study analyzed data from 6,222 adults from NHANES (2007–2012) to investigate the relationship between the oxidative balance score (OBS)—a composite index reflecting dietary and lifestyle factors affecting oxidative stress—and thyroid function, focusing on free thyroxine (FT4) and total thyroxine (TT4). Using weighted multivariable linear regression, the study found

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June 26, 2025 No Comments

Testosterone in Female Depression: A Meta-Analysis and Mendelian Randomization Study

This meta-analysis and Mendelian randomization study explores the relationship between serum testosterone levels and depression in women. While the meta-analysis indicates a significant association, particularly in premenopausal women, the Mendelian randomization analysis does not establish a causal link. These findings suggest that testosterone levels may act as a marker rather

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June 26, 2025 No Comments

Testosterone Therapy is Associated With Depression, Suicidality, and Intentional Self-Harm: Analysis of a National Federated Database

This meta-analysis and Mendelian randomization study explored the association between serum testosterone levels and depression in women, finding a significant correlation, particularly in premenopausal women, but only borderline significance in postmenopausal women. However, no causal relationship was established between testosterone levels and depression, suggesting that testosterone supplementation should not be

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June 26, 2025 No Comments