Well Referenced

Tag: longevity

Metformin improves putative longevity effectors in peripheral mononuclear cells from subjects with prediabetes. A randomized controlled trial

This randomized, single-blind, placebo-controlled trial evaluated the impact of metformin on longevity-associated pathways in 38 prediabetic individuals over two months. Participants received either metformin (1500 mg/day) or placebo. Metformin treatment led to significant improvements in metabolic parameters and insulin sensitivity. Notably, there was an increase in SIRT1 gene and protein

Read More »
June 26, 2025 No Comments

Leisure-time running reduces all-cause and cardiovascular mortality risk

This 2014 prospective cohort study analyzed data from 55,137 adults aged 18–100 over a 15-year period to assess the impact of leisure-time running on mortality. Approximately 24% of participants reported running. Compared to non-runners, runners exhibited a 30% lower risk of all-cause mortality and a 45% lower risk of cardiovascular

Read More »
June 26, 2025 No Comments

Implementation of longevity-promoting supplements and medications in public health practice: achievements, challenges and future perspectives

This 2017 review discusses the integration of geroprotective interventions, such as calorie restriction mimetics, autophagy inducers, and senolytics, into public health strategies. It highlights the potential of these interventions to extend healthspan and delay age-related diseases. The authors address challenges including regulatory hurdles, ethical considerations, and the need for robust

Read More »
June 26, 2025 No Comments

Factors That May Enhance Longevity: A Literature Review and a Comprehensive Update for Aesthetic Surgeons

This 2016 literature review identifies 14 factors positively influencing human longevity, including caloric restriction, physical activity, happiness, vitamin intake, vegetarian or Mediterranean diet, oriental practices, socioeconomic status, genetics, sexual activity, sleep, moderate wine consumption, religion, and education. The review emphasizes the importance of integrating these factors into postoperative care for

Read More »
June 26, 2025 No Comments

The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer

This 2013 review explores the dual role of the growth hormone (GH)–insulin–insulin-like growth factor-1 (IGF-1) signaling pathway in aging and cancer. In juveniles, GH promotes growth and sexual maturation; however, in adults, elevated GH/IGF-1 levels are associated with increased risks of cancer, insulin resistance, and diabetes. Studies in various organisms,

Read More »
June 26, 2025 No Comments

Blue Zones: Lessons From the World’s Longest Lived

This article, authored by Dan Buettner and Sam Skemp, investigates five regions globally—Okinawa (Japan), Sardinia (Italy), Nicoya Peninsula (Costa Rica), Ikaria (Greece), and Loma Linda (California, USA)—where people live significantly longer lives. These “Blue Zones” share nine lifestyle characteristics, termed the “Power 9,” which include natural movement, purposeful living, stress

Read More »
June 26, 2025 No Comments

Association of Dietary Magnesium Intake With Leukocyte Telomere Length in United States Middle-Aged and Elderly Adults

This 2022 observational study used data from 4,039 U.S. adults aged 45 and older (NHANES 1999–2002) to explore the relationship between dietary magnesium intake and leukocyte telomere length (LTL), a biomarker of cellular aging. Researchers found that higher magnesium intake was significantly associated with longer LTL, with participants consuming ≥299

Read More »
June 26, 2025 No Comments

Oxidative stress and exceptional human longevity: Systematic review

This systematic review analyzed 12 observational studies involving 646 centenarians and 1,052 younger controls to explore the relationship between oxidative stress (OS) and exceptional human longevity. The findings showed that long-lived individuals exhibited significantly lower oxidative damage to lipids and proteins (p

Read More »
June 26, 2025 No Comments

Might DHEA be considered a beneficial replacement therapy in the elderly?

The article “Might DHEA be considered a beneficial replacement therapy in the elderly?” explores the potential benefits of dehydroepiandrosterone (DHEA) supplementation as a hormone replacement therapy for age-related hormonal decline. DHEA levels naturally decrease with age, leading to physiological changes that may impact overall health. The study suggests that DHEA

Read More »
June 26, 2025 No Comments