Well Referenced

Tag: liver protection

Mechanisms of protection by the betaine-homocysteine methyltransferase/betaine system in HepG2 cells and primary mouse hepatocytes

This study examines the role of betaine-homocysteine methyltransferase (BHMT) and betaine in liver function, demonstrating that betaine supplementation enhances BHMT activity, reduces homocysteine levels, and increases S-adenosylmethionine (SAM) production. This metabolic shift protects liver cells from oxidative stress-induced apoptosis by reducing reactive oxygen species (ROS) and caspase activation. The findings

Read More »
June 26, 2025 No Comments

Taurine supplementation induces multidrug resistance protein 2 and bile salt export pump expression in rats and prevents endotoxin-induced cholestasis

This study investigates the effects of taurine supplementation on hepatic transport proteins, particularly multidrug resistance protein 2 (Mrp2) and bile salt export pump (Bsep), and its potential protective role against endotoxin-induced cholestasis in rats. The findings suggest that taurine enhances bile flow and reduces serum bilirubin levels by upregulating these

Read More »
June 26, 2025 No Comments