Well Referenced

Tag: liver health

NAFLD and nutraceuticals: a review of completed phase III and IV clinical trials

This 2023 systematic review analyzed 12 completed phase III and IV clinical trials registered on ClinicalTrials.gov, focusing on nutraceutical interventions for Nonalcoholic Fatty Liver Disease (NAFLD). The majority of studies investigated vitamin D (26.7%) and omega-3 fatty acids (20.0%), with others examining caffeine, chlorogenic acid, ginger, phosphatidylcholine, Trigonella foenum-graecum seed

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June 26, 2025 No Comments

The sulfur-containing amino acids: an overview

This review article discusses the roles of sulfur-containing amino acids—methionine, cysteine, homocysteine, and taurine—in human biochemistry. Methionine, an essential amino acid, is involved in methylation reactions and protein synthesis, while cysteine plays a crucial role in protein structure and is the precursor for glutathione and taurine. The metabolism of homocysteine,

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June 26, 2025 No Comments

Betaine attenuates hepatic steatosis by reducing methylation of the MTTP promoter and elevating genomic methylation in mice fed a high-fat diet

This study examined the effects of betaine supplementation on hepatic steatosis in mice fed a high-fat diet, with a focus on epigenetic mechanisms. Betaine was found to improve liver function by reducing methylation of the microsomal triglyceride transfer protein (MTTP) promoter, leading to increased MTTP expression, which plays a crucial

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June 26, 2025 No Comments

Effect of taurine on biliary excretion and metabolism of acetaminophen in male hamsters

Taurine supplementation was found to significantly enhance the biliary excretion of acetaminophen and its metabolites in male hamsters, particularly increasing the elimination of acetaminophen-glucuronide and acetaminophen-sulfate conjugates. This suggests that taurine supports phase II liver detoxification, promoting the clearance of acetaminophen and potentially reducing hepatotoxicity risk. The study implies that

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June 26, 2025 No Comments

Choline intake in a large cohort of patients with nonalcoholic fatty liver disease

This observational study examined the relationship between dietary choline intake and liver fibrosis severity in patients with nonalcoholic fatty liver disease (NAFLD). The findings revealed that postmenopausal women with lower choline intake had significantly worse fibrosis (p=0.002), even after adjusting for factors such as age, obesity, triglycerides, diabetes, alcohol use,

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June 26, 2025 No Comments

Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium

This symposium summary discusses the roles of S-adenosylmethionine (SAMe), folate, and betaine in treating alcoholic liver disease (ALD), focusing on their biochemical functions and therapeutic potential. These compounds act as methyl donors essential for hepatic transmethylation reactions, impacting homocysteine metabolism and influencing gene expression related to liver health. Deficiencies in

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June 26, 2025 No Comments

AdipoRon enhances healthspan in middle-aged obese mice: striking alleviation of myosteatosis and muscle degenerative markers

This study investigated the effects of AdipoRon, an adiponectin receptor agonist, on healthspan in obese middle-aged mice. The research found that chronic AdipoRon administration significantly improved insulin sensitivity, increased muscle and liver densities, and reduced myosteatosis, suggesting its potential to protect against muscle and liver degeneration linked to aging and

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June 26, 2025 No Comments