Effect of taurine on biliary excretion and metabolism of acetaminophen in male hamsters

Taurine supplementation was found to significantly enhance the biliary excretion of acetaminophen and its metabolites in male hamsters, particularly increasing the elimination of acetaminophen-glucuronide and acetaminophen-sulfate conjugates. This suggests that taurine supports phase II liver detoxification, promoting the clearance of acetaminophen and potentially reducing hepatotoxicity risk. The study implies that