liver function Archives - Well Referenced

Mesenchymal stem cell therapy in decompensated liver cirrhosis: a long-term follow-up analysis of the randomized controlled clinical trial

This 2021 randomized controlled trial evaluated the long-term safety and efficacy of umbilical cord-derived mesenchymal stem cell (UC-MSC) therapy in patients with hepatitis B virus (HBV)-related decompensated liver cirrhosis (DLC). A total of 250 patients were randomized to receive either standard care or standard care plus UC-MSC infusions at weeks

June 26, 2025 No Comments

Effects of silymarin supplementation on liver and kidney functions: A systematic review and dose-response meta-analysis

This meta-analysis reviewed the effects of silymarin supplementation on liver and kidney functions by analyzing data from 41 randomized controlled trials. The results showed significant reductions in liver enzymes (alkaline phosphatase, alanine transaminase, aspartate aminotransferase) and creatinine levels, as well as increased serum glutathione levels. Longer-duration and higher-dose silymarin supplementation

June 26, 2025 No Comments

A Randomized Trial of Silymarin for the Treatment of Nonalcoholic Steatohepatitis

This randomized, double-blind, placebo-controlled trial evaluated the efficacy of silymarin in patients with nonalcoholic steatohepatitis (NASH). While silymarin did not significantly reduce the NAFLD activity score (NAS) by 30% or more compared to placebo, it was associated with a significant reduction in liver fibrosis as measured by both histology and

June 26, 2025 No Comments

High-dose intravenous glutathione in man. Pharmacokinetics and effects on cyst(e)ine in plasma and urine

This randomized, double-blind, placebo-controlled trial evaluated the effects of intravenous glutathione in 30 patients with alcoholic liver disease (ALD). Patients treated with glutathione showed statistically significant improvements in liver enzyme levels—specifically reductions in GGT, AST, and ALT—indicating reduced liver inflammation and oxidative stress. The therapy was well-tolerated, with no significant

June 26, 2025 No Comments

Methionine restriction increases blood glutathione and longevity in F344 rats

This in vivo animal study explored the impact of lifelong methionine (Met) restriction on glutathione (GSH) levels and longevity in F344 rats. Researchers observed that Met-restricted rats experienced a 42% increase in mean lifespan and a 44% increase in maximum lifespan, alongside a 43% decrease in body weight (p <

June 26, 2025 No Comments

Choline’s role in maintaining liver function: new evidence for epigenetic mechanisms

This article reviews the crucial role of choline in maintaining liver function, focusing on how choline influences gene expression through epigenetic mechanisms like DNA and histone methylation. Choline is vital for generating S-adenosylmethionine, which regulates liver-related gene expression. A deficiency in choline can lead to liver issues such as fatty

June 26, 2025 No Comments

Taurine ameliorates cholesterol metabolism by stimulating bile acid production in high-cholesterol-fed rats

Taurine supplementation has been shown to significantly improve cholesterol metabolism in high-cholesterol-fed rats by stimulating bile acid synthesis and increasing cholesterol catabolism. The study found that taurine reduced serum cholesterol by 37% and hepatic cholesterol by 32%, while increasing fecal bile acid excretion and biliary bile acid concentrations. The taurine-conjugated

June 26, 2025 No Comments

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