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Tag: lipid peroxidation

Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: Analytical and biological challenges

This systematic review examines the challenges in assessing lipid peroxidation through biomarkers such as malondialdehyde (MDA), 4-hydroxy-nonenal (HNE), and 15(S)-8-iso-prostaglandin F₂α (15(S)-8-iso-PGF₂α), which indicate oxidative stress and cellular damage. These markers originate from both enzymatic and non-enzymatic reactions involving polyunsaturated fatty acids (PUFAs), complicating their accurate quantification. The review highlights

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June 26, 2025 No Comments

Malonaldehyde acts as a mitochondrial toxin: Inhibitory effects on respiratory function and enzyme activities in isolated rat liver mitochondria

This in vitro study examined the toxic effects of malonaldehyde (MDA), a product of lipid peroxidation, on mitochondrial function in isolated rat liver mitochondria. MDA exposure resulted in a dose-dependent decrease in oxygen consumption, indicating impaired mitochondrial respiratory function. The study also observed the inhibition of key mitochondrial enzymes, including

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June 26, 2025 No Comments

L-deprenyl protects against rotenone-induced, oxidative stress-mediated dopaminergic neurodegeneration in rats

This in vivo animal study investigated the neuroprotective effects of L-deprenyl against rotenone-induced dopaminergic neurodegeneration in rats. Rotenone, a mitochondrial complex-I inhibitor, induces oxidative stress and neuronal damage, mimicking Parkinson’s disease pathology. L-deprenyl treatment significantly reduced oxidative stress markers, preserved dopaminergic neurons in the substantia nigra, decreased lipid peroxidation, and

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June 26, 2025 No Comments