Well Referenced

Tag: lipid peroxidation

Iron Load Toxicity in Medicine: From Molecular and Cellular Aspects to Clinical Implications

This comprehensive review explores the multifaceted nature of iron toxicity, emphasizing the role of labile iron species in generating reactive oxygen species (ROS) that lead to oxidative stress, lipid peroxidation, and cellular damage. It discusses the molecular interactions of iron with dietary components, pharmaceuticals, and environmental toxins, highlighting their contribution

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June 26, 2025 No Comments

Reactive Oxygen Species and Antioxidants in Atopic Dermatitis

This 2017 review by Sivaranjani et al. explores the role of oxidative stress in the pathogenesis of atopic dermatitis (AD). The authors discuss how an imbalance between reactive oxygen species (ROS) and antioxidant defenses contributes to skin inflammation and barrier dysfunction in AD. Elevated levels of ROS can lead to

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June 26, 2025 No Comments

Role of Reactive Oxygen Species and Antioxidants in Atopic Dermatitis

This 2013 case-control study by Sivaranjani et al. assessed oxidative stress markers in 25 patients with atopic dermatitis (AD) compared to 25 healthy controls. The study found significantly elevated levels of malondialdehyde (MDA), a marker of lipid peroxidation, in AD patients. Concurrently, there was a marked reduction in both enzymatic

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June 26, 2025 No Comments

Ironing out the role of ferroptosis in immunity

This 2024 review article delves into the intricate relationship between ferroptosis—a regulated, iron-dependent form of cell death—and the immune system. It highlights how ferroptosis influences both innate and adaptive immunity, affecting processes such as infection response, autoimmunity, and tumor immunity. The review discusses the dual role of ferroptosis in promoting

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June 26, 2025 No Comments

CaNa2EDTA chelation attenuates cell damage in workers exposed to lead–a pilot study

This 2015 pilot study investigated the effects of CaNa₂EDTA chelation therapy on oxidative and genotoxic damage in smelting factory workers with chronic lead exposure averaging 5.8 ± 1.2 years. Following a five-day CaNa₂EDTA regimen, significant reductions were observed in oxidative stress biomarkers, including normalized activities of antioxidant enzymes (Cu,Zn-SOD and

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June 26, 2025 No Comments

Serum antioxidative enzymes levels and oxidative stress products in age-related cataract patients

This case-control study assessed oxidative stress and antioxidant enzyme levels in 60 patients with age-related cataracts compared to 60 healthy controls. Results showed significantly reduced serum activities of key antioxidant enzymes—superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px)—in cataract patients. Concurrently, levels of oxidative stress markers such as malondialdehyde

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June 26, 2025 No Comments

Markers of Oxidant Stress that are Clinically Relevant in Aging and Age-Related Disease

This 2013 review by Jacob et al. examines biomarkers indicative of oxidative stress in aging and associated diseases. It highlights markers such as 8-oxo-2′-deoxyguanosine (8-oxo-dG) for DNA oxidation, protein carbonyls for protein oxidation, and F2-isoprostanes for lipid peroxidation. The accumulation of these markers correlates with age-related conditions like cardiovascular diseases,

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June 26, 2025 No Comments

Ozonized autohemotransfusion improves hemorheological parameters and oxygen delivery to tissues in patients with peripheral occlusive arterial disease

This 2001 randomized controlled trial titled “Ozonized autohemotransfusion improves hemorheological parameters and oxygen delivery to tissues in patients with peripheral occlusive arterial disease” (Annals of Hematology, DOI: [10.1007/s002770100377*) evaluated the impact of ozonized autohemotransfusion in 27 patients with peripheral occlusive arterial disease (POAD) compared to 20 healthy controls. Patients receiving

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June 26, 2025 No Comments

A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress

This systematic review examines malondialdehyde (MDA), a product of polyunsaturated fatty acid peroxidation, highlighting its role as a toxic molecule and a biomarker of oxidative stress. MDA forms adducts with DNA and proteins, contributing to mutagenesis and atherogenesis, with elevated levels observed in oxidative stress-related conditions such as cardiovascular diseases

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June 26, 2025 No Comments