This study, published in the Annals of the New York Academy of Sciences in 1995 (PMID: 8597453), investigates the effects of dehydroepiandrosterone (DHEA) supplementation in aging men and women. DHEA was associated with increased anabolic growth factors, improved muscle strength and lean body mass, activated immune function, and enhanced quality
The article “The endocrine system and ageing” discusses the hormonal changes that occur with aging, including declines in estrogen, testosterone, growth hormone, and other key hormones, as well as increases in certain others like luteinizing hormone and sex hormone-binding globulin. These alterations contribute to various clinical consequences such as reduced
This clinical trial examined the effects of transdermal testosterone (T) gel in hypogonadal men, showing significant improvements in sexual function, mood, lean body mass, and muscle strength, particularly in the legs, while also reducing fat mass. The study compared daily doses of 50 mg and 100 mg T gel to
In this randomized controlled trial published in the Journal of Clinical Endocrinology & Metabolism in 2007 (PMID: 17390929), 100 hypogonadal men with type 2 diabetes aged 40–70 were randomized to receive either intramuscular testosterone enanthate (200 mg every two weeks) or placebo for 6 months to evaluate its effects on
