lean body mass Archives - Well Referenced

Activation of the central melanocortin system chronically reduces body mass without the necessity of long-term caloric restriction

This 2017 preclinical study investigated the long-term effects of activating the central melanocortin system via intracerebroventricular infusion of melanotan II (MTII), a potent melanocortin receptor agonist, in adult F344BN rats. Over a 40-day period, MTII administration led to a persistent reduction in body mass and adiposity, despite food intake returning

June 26, 2025 No Comments

Body Composition and Hormonal Adaptations Associated with Forskolin Consumption in Overweight and Obese Men

This 12-week randomized, double-blind, placebo-controlled study evaluated the effects of forskolin supplementation (250 mg of 10% extract twice daily) on body composition and hormonal profiles in 30 overweight and obese men. The forskolin group experienced significant reductions in body fat percentage and fat mass compared to placebo. There was also

June 26, 2025 No Comments

Obesity and sarcopenia after menopause are reversed by sex hormone replacement therapy

This 2001 randomized, placebo-controlled crossover study investigated the effects of combined hormone replacement therapy (HRT) with 17β-estradiol and norethisterone acetate on body composition in 16 healthy postmenopausal women. Over two 12-week periods separated by a 3-month washout, participants received either HRT or placebo. HRT led to significant increases in lean

June 26, 2025 No Comments

The response of muscle protein synthesis following whole-body resistance exercise is greater following 40 g than 20 g of ingested whey protein

This 2016 randomized crossover study investigated the effect of ingesting 20 g versus 40 g of whey protein on muscle protein synthesis (MPS) following whole-body resistance exercise in young resistance-trained men. Using stable isotope tracers and muscle biopsies, the study found that 40 g of whey protein stimulated a significantly

June 26, 2025 No Comments

Body composition and quality of life in adults with growth hormone deficiency; effects of low-dose growth hormone replacement

This prospective, open-label study evaluated the early effects of low-dose growth hormone replacement (GHR) on body composition and quality of life (QoL) in adults with growth hormone deficiency (AGHD). Patients received daily GH doses of 0.4–0.5 IU, titrated to maintain IGF-I levels between the median and upper end of the

June 26, 2025 No Comments

Testosterone as potential effective therapy in treatment of obesity in men with testosterone deficiency: a review

This 2012 review examines the potential role of testosterone therapy in managing obesity among hypogonadal men. Obesity impairs testicular testosterone production, leading to a cycle of increased fat accumulation, particularly visceral fat, which is associated with metabolic syndrome and type 2 diabetes. Testosterone therapy has been shown to reverse fat

June 26, 2025 No Comments

The Role of Anabolic Hormones for Wound Healing in Catabolic States

This comprehensive review examines the interplay between anabolic hormones, nutrition, and wound healing, particularly in catabolic states such as trauma, burns, and chronic illness. It highlights how deficiencies in key anabolic hormones—human growth hormone (HGH), insulin-like growth factor-1 (IGF-1), insulin, and testosterone—impair protein synthesis and lean body mass maintenance, leading

June 26, 2025 No Comments

Endocrine and metabolic effects of long-term administration of [Nle27]growth hormone-releasing hormone-(1-29)-NH2 in age-advanced men and women

This randomized controlled trial examined the effects of nightly administration of a growth hormone-releasing hormone (GHRH) analog, [Nle27]GHRH(1-29)-NH2, for four months in older adults. Significant anabolic benefits, such as increased lean body mass, improved insulin sensitivity (p

June 26, 2025 No Comments

Hormone replacement therapy and physical function in healthy older men. Time to talk hormones?

This review discusses the potential benefits of hormone replacement therapy (HRT), particularly testosterone and growth hormone (GH), in maintaining physical function in older men, especially those suffering from age-related declines in muscle mass and strength (sarcopenia). It highlights that while exercise is important, it may not be sufficient for older

June 26, 2025 No Comments

l-carnitine and cancer cachexia: Clinical and experimental aspects

This review article examines the role of L-carnitine in cancer cachexia, a syndrome characterized by muscle wasting, fatigue, weight loss, and reduced appetite in cancer patients. L-carnitine supplementation has been associated with improvements in lean body mass, reduced fatigue, and enhanced overall quality of life, although findings across studies remain

June 26, 2025 No Comments

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