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Tag: intravenous infusion

Efficacy and Safety of Umbilical Cord Mesenchymal Stem Cell Therapy for Rheumatoid Arthritis Patients: A Prospective Phase I/II Study

This prospective Phase I/II study evaluated the long-term safety and efficacy of intravenous umbilical cord-derived mesenchymal stem cell (UC-MSC) therapy combined with disease-modifying anti-rheumatic drugs (DMARDs) in 64 patients with rheumatoid arthritis (RA). Patients received 2 × 10⁷ UC-MSCs via intravenous infusion and were followed for up to 3 years.

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June 26, 2025 No Comments

Detection of chlorite, chlorate and perchlorate in ozonated saline

This 2020 study by Ma et al. investigated the formation of potentially harmful byproducts—chlorite, chlorate, and perchlorate—when ozone is introduced into normal saline, a practice used in certain ozone therapies. Utilizing ion chromatography-mass spectrometry (IC-MS), the researchers analyzed ozonated saline stored in two types of containers: polypropylene saline bottles and

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June 26, 2025 No Comments

Effect of intravenous polyunsaturated phosphatidylcholine infusion on insulin receptor processing and lipid composition of erythrocytes in patients with liver cirrhosis

This 1992 study investigated whether intravenous infusion of polyunsaturated phosphatidylcholine (PPC) could improve insulin receptor processing and alter erythrocyte membrane lipid composition in patients with liver cirrhosis. Thirteen cirrhotic patients received 2 g/day of PPC for 3 days. Post-treatment assessments showed a decreased erythrocyte cholesterol-to-phospholipid molar ratio and increased polyunsaturated

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June 26, 2025 No Comments

Pilot Phase I Clinical Trial of Methioninase on High-Stage Cancer Patients: Rapid Depletion of Circulating Methionine

This Phase I clinical trial evaluated the safety and efficacy of methioninase (METase) and recombinant methioninase (rMETase) in depleting serum methionine (MET) levels in high-stage cancer patients. MET dependence is a metabolic vulnerability in cancer cells, making MET depletion a potential therapeutic strategy. Three patients received non-recombinant METase, showing significant

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June 26, 2025 No Comments

Fever Therapy With Intravenously Applied Mistletoe Extracts for Cancer Patients: A Retrospective Study

This 2017 retrospective observational study (Integrative Cancer Therapies, PMID: 27387685) investigated the safety and immune-stimulating effects of intravenously applied mistletoe extracts (IAMPs) in 59 cancer patients receiving 567 total infusions. Fever (≥38.5°C) was successfully induced in 76% of patients, with an average temperature increase of 1.5°C. Most adverse events were

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June 26, 2025 No Comments

Effects of Intravenous Apolipoprotein A-I/phosphatidylcholine Discs on LCAT, PLTP, and CETP in Plasma and Peripheral Lymph in Humans

This randomized controlled trial examined the effects of intravenously administered apolipoprotein A-I/phosphatidylcholine (apoA-I/PC) discs on key enzymes involved in lipid metabolism and reverse cholesterol transport in human subjects. The infusion significantly increased pre-beta-HDL concentrations in plasma, enhanced lecithin:cholesterol acyltransferase (LCAT) activity to facilitate HDL maturation, and elevated phospholipid transfer protein

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June 26, 2025 No Comments