This randomized controlled trial examined the effects of intravenously administered apolipoprotein A-I/phosphatidylcholine (apoA-I/PC) discs on key enzymes involved in lipid metabolism and reverse cholesterol transport in human subjects. The infusion significantly increased pre-beta-HDL concentrations in plasma, enhanced lecithin:cholesterol acyltransferase (LCAT) activity to facilitate HDL maturation, and elevated phospholipid transfer protein
