Well Referenced

Tag: intestinal fatty acid-binding protein

Elevated Levels of Circulating Biomarkers Related to Leaky Gut Syndrome and Bacterial Translocation Are Associated With Graves’ Disease

This 2021 observational study published in Frontiers in Endocrinology (PMID: 34975767) explored the connection between intestinal barrier dysfunction and Graves’ disease (GD). In 91 patients with GD compared to 44 healthy controls, researchers found significantly elevated serum levels of lipopolysaccharide (LPS), intestinal fatty acid-binding protein (I-FABP), zonulin, and D-lactate (p

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June 26, 2025 No Comments

Noninvasive biomarkers of gut barrier function identify two subtypes of patients suffering from diarrhoea predominant-IBS: a case-control study

This 2018 case-control study published in BMC Gastroenterology (PMID: 30400824) investigated gut permeability and inflammation in patients with diarrhoea-predominant irritable bowel syndrome (D-IBS), identifying two subtypes based on intestinal barrier function. Among 39 D-IBS patients, 46.2% exhibited increased small-intestinal permeability as measured by lactulose/mannitol ratio, along with elevated levels of

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June 26, 2025 No Comments

Relevance of biomarkers indicating gut damage and microbial translocation in people living with HIV

This 2023 review published in Frontiers in Immunology (PMID: 37153621) investigates how gut permeability and microbial translocation contribute to systemic immune activation in people living with HIV (PLWH). It highlights key biomarkers—such as intestinal fatty acid-binding protein (I-FABP), zonulin, REG3α, lipopolysaccharide (LPS), and (1,3)-β-D-Glucan (BDG)—as tools to assess gut barrier

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June 26, 2025 No Comments