Well Referenced

Tag: hormone supplementation

Dehydroepiandrosterone (DHEA) effects on HIV replication and host immunity: a randomized placebo-controlled study

The randomized controlled trial titled “Dehydroepiandrosterone supplementation enhances immune function in HIV-positive subjects with undetectable viral load” (Clinical Infectious Diseases, 2007, PMID: 17263636) investigated whether supplementation with dehydroepiandrosterone (DHEA) could influence HIV replication and immune function. The study found that DHEA did not significantly alter viral load or CD4+ T-cell

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June 26, 2025 No Comments

Dehydroepiandrosterone (DHEA) Supplementation in Rheumatic Diseases: A Systematic Review

The systematic review titled “Dehydroepiandrosterone (DHEA) Supplementation in Rheumatic Diseases” (Mediterranean Journal of Rheumatology, 2023, DOI: 10.31138/mjr.20230825.dd) evaluated the effectiveness of DHEA in patients with systemic lupus erythematosus (SLE), Sjögren’s syndrome (SS), rheumatoid arthritis (RA), and fibromyalgia (FM) across 21 studies. DHEA supplementation notably improved bone mineral density, reduced fatigue,

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June 26, 2025 No Comments

Dehydroepiandrosterone, Cancer, and Aging

The review article titled “Dehydroepiandrosterone, Cancer, and Aging” (Aging and Disease, 2022, PMID: 35430962) evaluates the potential benefits of dehydroepiandrosterone (DHEA), the most abundant circulating steroid hormone, in preventing and managing age-related diseases, particularly cancer and metabolic disorders. It highlights DHEA’s proposed mechanism of action, including inhibition of glucose-6-phosphate dehydrogenase

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June 26, 2025 No Comments

DHEA Modulates Immune Function: A Review of Evidence

The systematic review titled “DHEA Modulates Immune Function: A Review of Evidence” (Vitamins and Hormones, 2018, PMID: 30029724) explores the immunomodulatory effects of dehydroepiandrosterone (DHEA) and its potential role in enhancing immune function. The review highlights DHEA’s ability to increase cytokine production, enhance natural killer (NK) cell activity, and improve

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June 26, 2025 No Comments

Low serum levels of sex steroids are associated with disease characteristics in primary Sjogren’s syndrome; supplementation with dehydroepiandrosterone restores the concentrations

The study “Low serum levels of sex steroids are associated with disease characteristics in primary Sjögren’s syndrome; supplementation with dehydroepiandrosterone restores the concentrations” investigated the impact of dehydroepiandrosterone (DHEA) supplementation on sex hormone levels and disease symptoms in postmenopausal women with primary Sjögren’s syndrome (pSS). In this randomized, placebo-controlled, 9-month

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June 26, 2025 No Comments