Well Referenced

Tag: heart failure

Safety and Efficacy of the Intravenous Infusion of Umbilical Cord Mesenchymal Stem Cells in Patients With Heart Failure: A Phase 1/2 Randomized Controlled Trial (RIMECARD Trial)

This Phase 1/2 double-blind, placebo-controlled trial assessed the safety and efficacy of intravenous allogeneic umbilical cord-derived mesenchymal stem cells (UC-MSCs) in 30 patients with chronic stable heart failure and reduced ejection fraction (HFrEF) under optimal medical therapy. Patients were randomized to receive a single infusion of UC-MSCs (1×10^6 cells/kg) or

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June 26, 2025 No Comments

Growth Hormone in Heart Failure Revisited: An Old Story Retold

This review revisits the role of growth hormone (GH) in heart failure (HF), highlighting its potential therapeutic benefits due to its anabolic, vasodilatory, and anti-apoptotic properties. Early studies suggested improvements in cardiovascular parameters with GH therapy; however, larger trials yielded inconsistent results. The authors discuss the concept of multiple hormonal

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June 26, 2025 No Comments

Cardiovascular Event Prediction by Machine Learning: The Multi-Ethnic Study of Atherosclerosis

This 2017 study utilized data from 6,814 participants in the Multi-Ethnic Study of Atherosclerosis (MESA) to evaluate the effectiveness of machine learning, specifically random survival forests, in predicting six cardiovascular outcomes over a 12-year follow-up. Incorporating 735 variables from imaging, biomarker panels, ECG, and questionnaires, the machine learning models outperformed

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June 26, 2025 No Comments

Effect of hormone replacement therapy on cardiovascular events in recently postmenopausal women: randomised trial

This 2012 randomized controlled trial assessed the long-term impact of hormone replacement therapy (HRT) on cardiovascular outcomes in 1,006 recently postmenopausal women aged 45–58. Participants received either HRT (17β-estradiol with or without norethisterone acetate) or no treatment and were followed for 10 years of therapy plus 6 years post-intervention. The

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June 26, 2025 No Comments

New Therapeutic Approach to Heart Failure Due to Myocardial Infarction Based on Targeting Growth Hormone-Releasing Hormone Receptor

This 2015 preclinical study by Kanashiro-Takeuchi et al. investigated the effects of growth hormone-releasing hormone (GHRH) agonists on myocardial infarction (MI)-induced heart failure. Using rodent models, the researchers administered GHRH agonists (JI-38, MR-356, and MR-409) and observed significant improvements in cardiac function, including reduced infarct size, enhanced vascular density, increased

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June 26, 2025 No Comments

NAD⁺ Metabolism in Cardiac Health, Aging, and Disease

This comprehensive review examines the pivotal role of NAD⁺ in cardiac physiology, aging, and disease. It details how NAD⁺ levels decline with age, obesity, and hypertension, contributing to cardiovascular diseases. The article discusses mechanisms of NAD⁺ metabolism in cardiomyocytes, including biosynthesis and degradation pathways, and the impact on mitochondrial function

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June 26, 2025 No Comments