This article provides a review of the use of nutraceuticals, including magnesium, riboflavin, coenzyme Q10, feverfew, and butterbur, for migraine prophylaxis. It highlights the growing body of evidence supporting the efficacy of these non-pharmacological treatments in reducing the frequency and severity of migraines, especially for patients dissatisfied with conventional medications.
This 2001 randomized controlled trial evaluated the effectiveness of intravenous magnesium sulfate in treating acute migraine attacks. Thirty patients were enrolled; those who received 1 g of magnesium over 15 minutes experienced significant improvements—86.6% became pain-free, and 100% reported relief from accompanying symptoms, compared to minimal improvement in the placebo
This 2022 randomized, double-blind, placebo-controlled trial published in Scientific Reports (DOI: 10.1038/s41598-021-04397-z, PMID: 34997178) evaluated the effects of alpha-lipoic acid (ALA) supplementation in 92 women with episodic migraines. Over 3 months, participants receiving 300 mg/day of ALA experienced significant reductions in headache frequency, severity, and duration, along with decreased levels
A systematic review published in the Cochrane Database of Systematic Reviews (2015) analyzed 12 trials with 201 participants to evaluate the effectiveness of normobaric oxygen therapy (NBOT) and hyperbaric oxygen therapy (HBOT) for treating and preventing migraines and cluster headaches. The findings suggest that NBOT is effective in providing rapid
This review examines the relationship between estrogen replacement therapy (ERT) and migraines in postmenopausal women, highlighting that stable estrogen levels achieved through ERT may help reduce migraine frequency in some individuals while triggering migraines in others. The study emphasizes the need for a personalized approach, as fluctuations in estrogen are
