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Tag: growth hormone–releasing hormone

Bioactivity of Growth Hormone Releasing Hormone (1-29) Analogues After SC Injection in Man

This 1989 study by Aitman et al. assessed the pharmacological effects of native GHRH(1-29)NH₂ and its synthetic analogue [Ac-D-Tyr¹,D-Ala²]-GHRH(1-29)NH₂ in healthy male volunteers following subcutaneous injection (3 µg/kg). Despite prior evidence of enhanced activity in animal models, the study found no significant differences between the native and analogue forms in

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June 26, 2025 No Comments

Growth hormone and prolactin secretion after growth hormone-releasing hormone administration, in anorexia nervosa patients, normal controls and tamoxifen-pretreated volunteers

This study assessed the effects of growth hormone-releasing hormone (GHRH) on growth hormone (GH) and prolactin (PRL) secretion in women with anorexia nervosa, normal controls, and tamoxifen-pretreated volunteers. Results showed that GHRH administration induced a GH peak in both anorexia nervosa patients and controls, suggesting that the hypothalamic-pituitary axis remains

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June 26, 2025 No Comments

Growth response to growth hormone-releasing hormone(1-29)-NH2 compared with growth hormone

This study compared the effectiveness of growth hormone-releasing hormone (GHRH(1-29)-NH₂) with standard growth hormone (GH) therapy in promoting growth in children with hypothalamic growth hormone deficiency (GHD). High-dose GHRH(1-29)-NH₂ significantly increased height velocity, comparable to GH treatment, but had no effect on bone age development. GHRH(1-29)-NH₂ did not induce GH

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June 26, 2025 No Comments

Pharmacokinetics of growth hormone-releasing hormone(1-29)-NH2 and stimulation of growth hormone secretion in healthy subjects after intravenous or intranasal administration

This study examined the pharmacokinetics of growth hormone-releasing hormone (GHRH(1-29)-NH₂) and its ability to stimulate growth hormone (GH) secretion. The results showed that the administration of GHRH(1-29)-NH₂ significantly increased GH levels in participants, with a dose-dependent effect observed. This suggests that GHRH(1-29)-NH₂ could be a potential therapeutic agent for stimulating

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June 26, 2025 No Comments

Polyethylene glycol-conjugated growth hormone-releasing hormone is long acting and stimulates GH in healthy young and elderly subjects

This study evaluated the pharmacokinetics and efficacy of polyethylene glycol (PEG)-conjugated growth hormone-releasing hormone (GHRH) in healthy young and elderly subjects. The results showed that PEG-GHRH has an extended half-life compared to native GHRH, leading to prolonged GH secretion in both age groups. The GH response was dose-dependent, with higher

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June 26, 2025 No Comments

Effects of growth hormone–releasing hormone on cognitive function in adults with mild cognitive impairment and healthy older adults: results of a controlled trial

A randomized controlled trial published in Archives of Neurology (PMID: 22869065) examined the effects of growth hormone–releasing hormone (GHRH) on cognitive function in adults with mild cognitive impairment (MCI) and healthy older adults. Over 20 weeks, participants received daily subcutaneous injections of GHRH or a placebo. The study found that

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June 26, 2025 No Comments