glycolysis Archives - Well Referenced

Association of Terazosin, Doxazosin, or Alfuzosin Use and Risk of Dementia With Lewy Bodies in Men

This 2024 retrospective cohort study analyzed data from over 600,000 men to assess whether the use of glycolysis-enhancing α1-adrenergic receptor antagonists—terazosin, doxazosin, or alfuzosin (Tz/Dz/Az)—is associated with a reduced risk of developing dementia with Lewy bodies (DLB). Compared to men taking tamsulosin or 5α-reductase inhibitors (5ARIs), those on Tz/Dz/Az had

June 26, 2025 No Comments

Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH

This 2015 study revealed that high-dose vitamin C selectively induces cytotoxicity in colorectal cancer (CRC) cells with KRAS or BRAF mutations by targeting the glycolytic enzyme GAPDH. The mechanism involves enhanced uptake of dehydroascorbate (DHA) via GLUT1 transporters, followed by intracellular reduction to vitamin C, which consumes glutathione and leads

June 26, 2025 No Comments

Vitamin C uncouples the Warburg metabolic switch in KRAS mutant colon cancer

This 2016 study investigated the metabolic effects of vitamin C on KRAS mutant colorectal cancer (CRC) cells. It found that vitamin C disrupts the Warburg effect by impairing glycolysis through several mechanisms: detachment of RAS from the plasma membrane, inhibition of ERK1/2 signaling, and reduction in PKM2 Ser37 phosphorylation. These

June 26, 2025 No Comments

Mitochondrial-Stem Cell Connection: Providing Additional Explanations for Understanding Cancer

This review introduces the Mitochondrial-Stem Cell Connection (MSCC) hypothesis, suggesting that chronic oxidative phosphorylation (OxPhos) insufficiency in stem cells leads to the formation of cancer stem cells (CSCs) and drives tumorigenesis. The hypothesis explains metabolic alterations in cancer, where cells compensate for OxPhos deficiency by upregulating glycolysis and glutaminolysis. Dysfunctional

June 26, 2025 No Comments

Tag: glycolysis

Association of Terazosin, Doxazosin, or Alfuzosin Use and Risk of Dementia With Lewy Bodies in Men

Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH

Vitamin C uncouples the Warburg metabolic switch in KRAS mutant colon cancer

Mitochondrial-Stem Cell Connection: Providing Additional Explanations for Understanding Cancer