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Tag: GHRH

Growth hormone-releasing hormone and its analogues in health and disease

This review explores the diverse biological effects of growth hormone-releasing hormone (GHRH) and its analogues, highlighting their potential therapeutic applications across various medical conditions. GHRH and its analogues stimulate cell growth, tissue repair, and wound healing, regulate apoptosis, modulate inflammation and immune responses, and offer neuroprotective effects, making them promising

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June 26, 2025 No Comments

Growth Hormone-Releasing Hormone and Its Analogues: Significance for MSCs-Mediated Angiogenesis

This review explores the role of growth hormone-releasing hormone (GHRH) and its analogues in enhancing mesenchymal stromal cell (MSC)-mediated angiogenesis and tissue repair. GHRH analogues activate the STAT3 signaling pathway in MSCs, promoting angiogenesis and regenerative processes, while GHRH antagonists inhibit these pathways and may serve as potential antitumor agents.

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June 26, 2025 No Comments

Interaction of the growth hormone releasing peptide hexarelin with somatostatin

This study investigated the interaction between hexarelin, a growth hormone-releasing peptide, and somatostatin, which inhibits growth hormone (GH) release. The results showed that somatostatin and hexarelin counteract each other’s effects on GH secretion, with somatostatin inhibiting and hexarelin stimulating GH release. The combination of hexarelin with growth hormone-releasing hormone (GHRH)

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June 26, 2025 No Comments

The interaction between clonidine and growth hormone releasing hormone in the stimulation of growth hormone secretion in man

This randomized controlled trial (PMID: 2147600) investigated the interaction between clonidine and GHRH on GH secretion in 6 healthy adult males. Peak GH concentrations were significantly higher when GHRH was given during rising GH levels (52.9 mU/L) compared to falling (27.5 mU/L) or stable (20.6 mU/L) levels (P=0.004). Clonidine-induced GH

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June 26, 2025 No Comments