Well Referenced

Tag: geriatrics

Intake of Vegetables, Fruits, Beta-Carotene, Vitamin C and Vitamin Supplements and Cancer Incidence Among the Elderly: A Prospective Study

This prospective study investigated the association between dietary intake of vegetables, fruits, beta-carotene, vitamin C, and vitamin supplements with cancer incidence in an elderly population. Conducted among older adults, the research found that higher consumption of vegetables and fruits was significantly associated with a reduced risk of certain cancers, supporting

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June 26, 2025 No Comments

Association of Markers of Inflammation, the Kynurenine Pathway and B Vitamins with Age and Mortality, and a Signature of Inflammaging

This study investigated the relationships between inflammatory markers, kynurenine pathway metabolites, B vitamins, age, and mortality in a cohort of 1,839 older adults. Results indicated that elevated levels of inflammatory markers and kynurenine pathway metabolites were associated with increased age and higher mortality risk. Conversely, higher concentrations of certain B

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June 26, 2025 No Comments

B Vitamins and Fatty Acids: What Do They Share with Small Vessel Disease-Related Dementia?

This comprehensive review explores the roles of B vitamins (notably B2, B6, B12) and fatty acids in the pathogenesis and potential treatment of small vessel disease-related dementia (SVD). B vitamins are implicated in endothelial protection, homocysteine metabolism, and neuroinflammation modulation, while fatty acids contribute to membrane integrity and anti-inflammatory processes.

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June 26, 2025 No Comments

B vitamins and prevention of cognitive decline and incident dementia: a systematic review and meta-analysis

This meta-analysis of 95 studies (n=46,175) evaluated the impact of B vitamin supplementation (folate, B6, B12) on cognitive decline and dementia risk. B vitamin supplementation was associated with a modest but statistically significant slowing of cognitive decline, particularly in non-demented individuals and with interventions lasting over 12 months. Higher dietary

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June 26, 2025 No Comments

B vitamins and the aging brain

This review explores the association between deficiencies in folate, vitamin B12, and vitamin B6 and neurological and psychological dysfunctions, including cognitive impairment and dementia in the elderly. Elevated plasma homocysteine levels, often resulting from inadequate B vitamin status, are implicated in neurotoxicity, vasotoxicity, and impaired methylation reactions essential for central

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June 26, 2025 No Comments

Effectiveness of B Vitamins and Their Interactions with Aspirin in Improving Cognitive Functioning in Older People with Mild Cognitive Impairment: Pooled Post-Hoc Analyses of Two Randomized Trials

This pooled post-hoc analysis of two randomized placebo-controlled trials assessed the impact of B vitamin supplementation (vitamin B12, folic acid, with or without vitamin B6) on cognitive function and brain atrophy in 545 older adults with mild cognitive impairment (MCI). Over 24 months, B vitamin supplementation significantly reduced whole brain

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June 26, 2025 No Comments

Folate, vitamin B12 and vitamin B6 and one carbon metabolism

This review article discusses the crucial roles of folic acid, vitamin B12, vitamin B6, and vitamin B2 in one-carbon metabolism. These vitamins serve as coenzymes facilitating the transfer of one-carbon units essential for DNA and RNA synthesis, methylation reactions, and amino acid metabolism. Disruptions in this pathway, often due to

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June 26, 2025 No Comments

Folic Acid and Vitamin B12 Supplementation and the Risk of Cancer: Long-term Follow-up of the B Vitamins for the Prevention of Osteoporotic Fractures (B-PROOF) Trial

This long-term follow-up study of the B-PROOF trial assessed the impact of daily supplementation with folic acid (400 μg) and vitamin B12 (500 μg) on cancer incidence among 2,524 older adults over 2–3 years. The findings revealed a 25% increased risk of overall cancer (HR 1.25; 95% CI, 1.00–1.53; P

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June 26, 2025 No Comments

Recent advances in biomarkers for senescence: Bridging basic research to clinic

This 2025 systematic review published in Geriatrics and Gerontology International (DOI: 10.1111/ggi.15054) explores the latest advances in biomarkers for cellular senescence, emphasizing their potential role in diagnosing and treating age-related diseases. The review discusses various biomarkers such as senescence-associated β-galactosidase, DNA-damage-related markers, and the senescence-associated secretory phenotype (SASP). It highlights

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June 26, 2025 No Comments