Well Referenced

Tag: geriatrics

Surgery-Induced Inflammation in Relation to Age, Muscle Endurance, and Self-Perceived Fatigue

In this 2010 prospective study published in The Journals of Gerontology: Series A, Bautmans et al. investigated the interplay between postoperative inflammation, age, muscle function, and fatigue. Sixty-six patients aged 24–91 undergoing elective abdominal surgery were assessed preoperatively and on postoperative days 2 and 4. Measurements included grip strength, muscle

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June 26, 2025 No Comments

Sarcopenia: revised European consensus on definition and diagnosis

This 2019 consensus by the European Working Group on Sarcopenia in Older People (EWGSOP2) redefines sarcopenia as a muscle disease characterized primarily by low muscle strength. Diagnosis involves a stepwise approach: (1) identifying probable sarcopenia through low muscle strength; (2) confirming diagnosis by assessing low muscle quantity or quality; and

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June 26, 2025 No Comments

Cumulative Lead Exposure and Prospective Change in Cognition Among Elderly Men: The VA Normative Aging Study

This longitudinal study examined the relationship between cumulative lead exposure and cognitive decline in elderly men participating in the VA Normative Aging Study. Researchers measured bone lead levels using K-shell X-ray fluorescence and assessed cognitive function through a battery of neuropsychological tests over several years. The findings indicated that higher

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June 26, 2025 No Comments

Effect of Selenium Supplementation on Changes in HbA1c: Results from a Multiple-Dose, Randomized Controlled Trial

This 2019 randomized, double-blind, placebo-controlled trial, published in Diabetes, Obesity and Metabolism, assessed the impact of selenium supplementation on glycemic control, specifically HbA1c levels, in a cohort of 491 adults aged 60–74 years without diabetes at baseline. Participants were randomized to receive 100 µg/day, 200 µg/day of selenium, or a

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June 26, 2025 No Comments

Exogenous Amino Acids Stimulate Net Muscle Protein Synthesis in the Elderly

This 1998 study published in The Journal of Clinical Investigation by Volpi et al. examined the impact of intravenous amino acid infusion on muscle protein metabolism in healthy elderly individuals (average age 71 ± 2 years). Utilizing stable isotope tracers, femoral arterio-venous catheterization, and muscle biopsies, the researchers assessed muscle

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June 26, 2025 No Comments

Lysine Requirement Through the Human Life Cycle

This 2007 review by Tomé and Bos, published in The Journal of Nutrition, examines lysine requirements across different life stages, emphasizing its role as an indispensable amino acid crucial for protein synthesis. The authors highlight that lysine cannot be synthesized by mammals and must be obtained through diet. They discuss

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June 26, 2025 No Comments

Zinc Supplementation Decreases Incidence of Infections in the Elderly: Effect of Zinc on Generation of Cytokines and Oxidative Stress

This 2007 randomized, double-blind, placebo-controlled trial, published in The American Journal of Clinical Nutrition, investigated the effects of zinc supplementation on infection incidence, cytokine production, and oxidative stress in elderly individuals. The study enrolled 50 healthy adults aged 55–87 years, who received either 45 mg/day of elemental zinc as zinc

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June 26, 2025 No Comments

Aerobic Exercise Restores Aging-Associated Reductions in Arterial Adropin Levels and Improves Adropin-Induced Nitric Oxide-Dependent Vasorelaxation

This 2021 study by Fujie et al. investigated the impact of aerobic exercise on arterial adropin levels and adropin-induced nitric oxide (NO)-dependent vasorelaxation in aging mice. The researchers found that aging was associated with decreased arterial adropin expression and impaired adropin-induced vasorelaxation due to reduced endothelial NO synthase (eNOS) phosphorylation.

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June 26, 2025 No Comments

Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans

This randomized controlled trial assessed the effects of alternate-day fasting (ADF) on physiological and molecular aging markers in healthy, non-obese adults. Over a 4-week period, participants following ADF experienced a 4.5% reduction in body weight and improved fat-to-lean mass ratio, particularly reducing trunk fat. Cardiovascular benefits included decreased systolic blood

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June 26, 2025 No Comments