This review article examines the role of L-carnitine in cancer cachexia, a syndrome characterized by muscle wasting, fatigue, weight loss, and reduced appetite in cancer patients. L-carnitine supplementation has been associated with improvements in lean body mass, reduced fatigue, and enhanced overall quality of life, although findings across studies remain
This randomized, double-blind, placebo-controlled trial investigated the effects of L-carnitine supplementation on physical and mental fatigue, cognitive function, and body composition in centenarians. Participants receiving 2 grams of levocarnitine daily experienced significant reductions in fat mass (-1.80 kg vs. +0.6 kg; P < 0.01), increases in muscle mass (+3.80 kg
This observational study examined the effects of intravenous L-carnitine on myocardial fatty acid metabolism in hemodialysis patients, with the goal of identifying responders and non-responders to the treatment. The study found that intravenous L-carnitine increased plasma carnitine levels, reduced fatigue, and helped maintain peak exercise capacity in patients. These results
This randomized controlled trial investigated the effects of intravenous L-carnitine supplementation on plasma carnitine levels, fatigue, and exercise capacity in hemodialysis patients over 24 weeks. L-carnitine significantly increased plasma carnitine concentrations and was associated with a smaller decline in peak oxygen consumption (VO₂max) compared to placebo (-0.05 ± 0.19 vs.
A 2016 meta-analysis published in Experimental and Therapeutic Medicine (PMID: 26998003) evaluated the efficacy and safety of testosterone replacement therapy (TRT) in men with hypogonadism, analyzing data from 16 randomized controlled trials. The study found that TRT effectively alleviates symptoms such as low libido, fatigue, and reduced muscle mass while
