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Tag: FAK

Lunasin sensitivity in non-small cell lung cancer cells is linked to suppression of integrin signaling and changes in histone acetylation

This 2014 study investigates the differential sensitivity of non-small cell lung cancer (NSCLC) cell lines to lunasin, a soy-derived peptide with anticancer properties. The research compares lunasin-sensitive H661 cells to resistant H1299 cells, revealing that lunasin internalization is higher in H661 cells. Lunasin interacts with integrins containing αv, α5, β1,

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June 26, 2025 No Comments

Cellular Signaling Pathways Modulated by Low-Intensity Extracorporeal Shock Wave Therapy

This 2019 review elucidates the molecular mechanisms by which low-intensity extracorporeal shock wave therapy (Li-ESWT) exerts therapeutic effects, particularly in erectile dysfunction (ED). Li-ESWT promotes neovascularization, tissue regeneration, and anti-inflammatory responses through mechanotransduction, leading to activation of key signaling pathways such as FAK, ERK1/2, Wnt/β-catenin, PI3K/Akt/mTOR, and PERK/ATF4. These pathways

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June 26, 2025 No Comments