This 2023 randomized controlled trial investigated the impact of sleep duration and quality on weight loss maintenance in adults with obesity. After an initial 8-week low-calorie diet resulting in an average weight loss of 13.1 kg, participants were monitored over a 1-year maintenance phase. Those with short sleep duration (5)
This 2024 secondary analysis of a randomized clinical trial examined the effects of exercise, GLP-1 receptor agonist (liraglutide) treatment, and their combination on bone health in adults with obesity. After an initial 8-week low-calorie diet, 195 participants were randomized into four groups: exercise alone, liraglutide alone, combination of both, or
This review explores the physiological and molecular effects of caloric restriction (CR), exercise, and pharmacological mimetics on aging and metabolic health. CR has been shown to extend both mean and maximum lifespan in animal models by activating stress response pathways and enhancing mitochondrial function. Exercise primarily improves healthspan, delaying the
This randomized controlled trial evaluated the impact of green tea catechin supplementation on exercise-induced fat loss in 132 overweight and obese adults over 12 weeks. Participants consumed a beverage containing ~625 mg catechins and 39 mg caffeine or a control beverage with caffeine only, while engaging in ≥180 minutes/week of
This systematic review and meta-analysis evaluated eight randomized controlled trials involving 1,022 overweight or obese adults (BMI ≥25) to compare the effectiveness of combined behavioral weight management programs (BWMPs) incorporating both diet and physical activity versus diet-only or physical activity-only interventions. Short-term (3–6 months) weight loss was similar between combined
This 2016 review by Merghani, Malhotra, and Sharma explores the complex relationship between exercise volume and cardiac health. While moderate physical activity is well-established in reducing cardiovascular morbidity and mortality, the authors highlight emerging evidence suggesting that excessive endurance exercise may lead to adverse cardiac outcomes. These include myocardial fibrosis,
This 2015 review by Stewart J. Tepper evaluates the evidence supporting nutraceutical, biobehavioral, and physical treatments for migraine and other headache disorders. For migraine prevention in adults, Level B evidence supports the use of feverfew, magnesium, and riboflavin (vitamin B2). Coenzyme Q10 (CoQ10) has Level C evidence, while melatonin has
This randomized controlled trial evaluated the effects of weight loss, with or without exercise, on serum sclerostin levels and hip geometry in 107 obese adults aged ≥65 years. Participants were assigned to one of four groups: control, diet-induced weight loss, exercise, or combined diet-exercise, over 12 months. The diet group
This study investigated whether bone mineral density (BMD) lost during weight reduction in postmenopausal women is recovered upon weight regain. Twenty-three overweight or obese postmenopausal women underwent a 6-month exercise-based weight loss program, losing an average of 3.9 ± 3.5 kg. Over the subsequent 12 months, they regained approximately 2.9
This 2011 randomized controlled trial assessed the impact of omega-3 fatty acid supplementation combined with dietary and exercise counseling on weight loss and body composition in overweight and obese adults. Over 24 weeks, participants in both the omega-3 and placebo groups lost more than 5% of their body weight. However,
